Pharmacological significance of triazole scaffold
Pharmacological significance of triazole scaffold
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DOI：
10.3109/14756360903524304
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发表时间：
2011-02-01
影响因子：
5.6
通讯作者：
Yar, Mohammed Shahar
中科院分区：
文献类型：
--
作者：
Kharb, Rajeev;Sharma, Prabodh Chander;Yar, Mohammed Shahar
三唑环是最重要和最知名的杂环之一，是各种天然产物和药物的共同和不可分割的特征。三唑核作为核心结构组分存在于一系列药物类别中，例如抗微生物剂、抗炎剂、镇痛剂、抗癫痫剂、抗病毒药、抗抑郁剂、抗高血压剂、抗疟疾剂、局部麻醉剂、抗焦虑剂、抗抑郁剂、抗组胺剂、抗氧化剂、抗结核剂、抗帕金森病剂、抗糖尿病剂、抗肥胖剂和免疫调节剂，等。三唑及其衍生物广泛而有效的活性使其成为具有药理学意义的支架。存在于各种药剂中的基本杂环是1，2，3-三唑和1，2，4-三唑。人们对三唑及其衍生物进行了大量的研究，证明了这种杂环核的药理重要性。本文综述了近年来有关三唑类衍生物的药理活性的研究进展，并对这类核的最新研究成果进行了综述。
The triazole nucleus is one of the most important and well known heterocycles which is a common and integral feature of a variety of natural products and medicinal agents. Triazole nucleus is present as a core structural component in an array of drug categories such as antimicrobial, anti-inflammatory, analgesic, antiepileptic, antiviral, antineoplastic, antihypertensive, antimalarial, local anaesthetic, antianxiety, antidepressant, antihistaminic, antioxidant, antitubercular, anti-Parkinson''s, antidiabetic, antiobesity and immunomodulatory agents, etc. The broad and potent activity of triazole and their derivatives has established them as pharmacologically significant scaffolds. The basic heterocyclic rings present in the various medicinal agents are 1,2,3-triazole and 1,2,4-triazole. A large volume of research has been carried out on triazole and their derivatives, which has proved the pharmacological importance of this heterocyclic nucleus. The present paper is an attempt to review the pharmacological activities reported for triazole derivatives in the current literature with an update of recent research findings on this nuclei.