Comparative analysis of histologic homologues of endometrial and ovarian carcinoma
Comparative analysis of histologic homologues of endometrial and ovarian carcinoma
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DOI：
10.1097/00000478-199803000-00006
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发表时间：
1998-03-01
影响因子：
5.6
通讯作者：
Frank, TS
中科院分区：
文献类型：
--
作者：
Caduff, RF;Svoboda-Newman, SM;Frank, TS
我们比较了组织学同源性卵巢癌和子宫癌的分子改变，包括17 q（家族性乳腺-卵巢癌基因BRCA 1内和远端）标记物等位基因缺失的患病率，Ki-ras密码子12的突变以及子宫和卵巢浆液性癌和乳头状浆液性癌中p53和c-erbB 2基因产物的免疫组化表达。共86例子宫和28例卵巢浆液性癌，以及8例子宫和26例卵巢乳头状浆液性癌，进行了评价。p53基因产物免疫反应性的患病率是相似的乳头状浆液性癌发生在子宫（6/8，75%）和卵巢（16/26，62%）。17 q等位基因丢失在子宫乳头状浆液性癌（7例中3例，43%）和卵巢乳头状浆液性癌（25例中16例，64%）中也有相似的高比例。相反，p53基因产物在卵巢类腺瘤中的表达（14/28，50%）明显多于子宫类腺瘤（4/86，5%）（p < 0.0001）。17 q等位基因丢失在卵巢癌（19或27，70%）中也明显多于子宫癌（2/72，3%）（p < 0.0001）。少数癌组织中存在c-erbB 2表达和Ki-ms第12密码子突变。卵巢和子宫内膜的子宫内膜样肿瘤，虽然组织学上相似，但可能是由不同的遗传事件引起的，而子宫乳头状浆液性癌与卵巢癌有几个共同的分子改变，这可能是其侵袭性临床行为的原因。
We compared molecular alterations in histologically homologous ovarian and uterine carcinomas, including the prevalence of allelic loss of markers on 17q (within and distal to the familial breast-ovarian cancer gene BRCA1), mutations of codon 12 of Ki-ras and immunohistochemical expression of the p53 and c-erbB2 gene products in endometrioid and papillary serous carcinomas occurring in the uterus and ovary. A total of 86 uterine and 28 ovarian endometrioid carcinomas, as well as 8 uterine and 26 ovarian papillary serous carcinomas, were evaluated. The prevalence of p53 gene product immunoreactivity was similar in papillary serous carcinomas occurring in the uterus (6 of 8, 75%) and ovary (16 of 26, 62%). Allelic loss on 17q also was seen in similarly high proportions of uterine (3 of 7, 43%) and ovarian (16 of 25, 64%) papillary serous carcinomas. In contrast, expression of the p53 gene product was seen in significantly more endometrioid tumors of the ovary (14 of 28, 50%) than in those occurring in the uterus (4 of 86, 5%) (p < 0.0001). Allelic loss on 17q also was present in significantly more ovarian (19 or 27, 70% than in uterine (2 of 72, 3%) endometrioid carcinomas (p < 0.0001). Immunohistochemical expression of c-erbB2 and mutations of codon 12 of Ki-ms were present in a minority of carcinomas. Endometrioid tumors of the ovary and endometrium, although histologically similar, may arise from different genetic events, whereas uterine papillary serous carcinoma shares with its ovarian counterpart several molecular alterations that may account for its aggressive clinical behavior.