The dipeptide Pro-Asp promotes IGF-1 secretion and expression in hepatocytes by enhancing JAK2/STAT5 signaling pathway
The dipeptide Pro-Asp promotes IGF-1 secretion and expression in hepatocytes by enhancing JAK2/STAT5 signaling pathway
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二肽Pro-Asp通过增强JAK2/STAT5信号通路促进肝细胞IGF-1分泌和表达
DOI：
10.1016/j.mce.2016.07.028
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发表时间：
2016-11
影响因子：
4.1
通讯作者：
Qingyan Jiang
中科院分区：
文献类型：
--
作者：
Songbo Wang;Guoqing Wang;Mengyuan Zhang;Lu Zhuang;Xiaojuan Wan;Jingren Xu;Lina Wang;Xiaotong Zhu;Ping Gao;Qianyun Xi;Yongliang Zhang;Gang Shu;Qingyan Jiang
It has been implicated that IGF-1 secretion can be regulated by dietary protein. However, whether the dipeptides, one of digested products of dietary protein, have influence on IGF-1 secretion remain largely unknown. Our study aimed to investigate the effects of the dipeptide Pro-Asp on IGF-1 secretion and expression in hepatocytes and to explore the possible underlying mechanisms. Our findings demonstrated that Pro-Asp promoted the secretion and gene expression of IGF-1 in HepG2 cells and primary porcine hepatocytes. Meanwhile, Pro-Asp activated the ERK and Akt signaling pathways, downstream of IGF-1. In addition, Pro-Asp enhanced GH-mediated JAK2/STAT5 signaling pathway, while inhibition of JAK2/STAT5 blocked the promotive effect of Pro-Asp on IGF-1 secretion and expression. Moreover, acute injection of Pro-Asp stimulated IGF-1 expression and activated JAK2/STAT5 signaling pathway in mice liver. Together, these results suggested that the dipeptide Pro-Asp promoted IGF-1 secretion and expression in hepatocytes by enhancing GH-mediated JAK2/STAT5 signaling pathway.
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DOI：
10.1016/j.nut.2015.02.011
发表时间：
2015-07
期刊：
Nutrition (Burbank, Los Angeles County, Calif.)
影响因子：
--
作者：
Dukes A;Davis C;El Refaey M;Upadhyay S;Mork S;Arounleut P;Johnson MH;Hill WD;Isales CM;Hamrick MW
通讯作者：
Hamrick MW
影响因子：
3.3
作者：
S. Hursting
通讯作者：
S. Hursting
影响因子：
4.8
作者：
Han, YL;Leaman, DW;Stark, GR
通讯作者：
Stark, GR
影响因子：
--
作者：
C. Pao;P. Farmer;Svijetlana Begovic;B. C. Villafuerte;Guang-Jer Wu;D. Robertson;L. Phillips
通讯作者：
C. Pao;P. Farmer;Svijetlana Begovic;B. C. Villafuerte;Guang-Jer Wu;D. Robertson;L. Phillips
影响因子：
2.7
作者：
Yaoyao Jia;Jong-Ho Kim;Bora Nam;Jiyoung Kim;Ji Hae Lee;K. Hwang;Sung-Joon Lee
通讯作者：
Yaoyao Jia;Jong-Ho Kim;Bora Nam;Jiyoung Kim;Ji Hae Lee;K. Hwang;Sung-Joon Lee