The fibroblast response to tubes exhibiting internal nanotopography
The fibroblast response to tubes exhibiting internal nanotopography
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DOI：
10.1016/j.biomaterials.2005.01.046
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发表时间：
2005-08-01
期刊：
影响因子：
14
通讯作者：
Affrossman, S
中科院分区：
文献类型：
--
作者：
Berry, CC;Dalby, MJ;Affrossman, S
三维支架在细胞和组织工程中的使用很广泛；然而，这种支架的使用带有额外的细胞提示，如纳米拓扑学，还处于初级阶段。本文详细介绍了用聚合物分离法制备具有纳米形貌的尼龙管的新方法，并报道了形貌对成纤维细胞的黏附、铺展、形态和细胞骨架组织有很大的影响。使用这样的框架，既能为组织形成提供正确的机械支持，又能通过地形线索刺激细胞，可能会为未来智能材料和支架的生产铺平道路。(C)2005爱思唯尔有限公司。保留所有权利。
The use of three-dimensional scaffolds in cell and tissue engineering is widespread; however, the use of such scaffolds, which bear additional cellular cues such as nanotopography, is as yet in its infancy. This paper details the novel fabrication of nylon tubes bearing nanotopography via polymer demixing, and reports that the topography greatly influenced fibroblast adhesion, spreading, morphology and cytoskeletal organisation. The use of such frameworks that convey both the correct mechanical support for tissue formation and stimulate cells through topographical cues may pave the way for future production of intelligent materials and scaffolds. (c) 2005 Elsevier Ltd. All rights reserved.