Preparation and optimization of quercetin-loaded liposomes for wound healing, using response surface methodology
Preparation and optimization of quercetin-loaded liposomes for wound healing, using response surface methodology
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DOI：
10.3109/21691401.2014.975238
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发表时间：
2016-02-17
影响因子：
5.8
通讯作者：
Singh, Deependra
中科院分区：
文献类型：
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作者：
Jangde, Rajendra;Singh, Deependra
本研究的基本目的是采用薄膜水合法制备槲皮素脂质体。采用响应面法（RSM）对脂质体处方进行优化。最终确定75 rpm的旋转速度和46 ℃的水浴温度是优化载药脂质体制剂的最佳条件。通过包封率（EE）、药物释放（DR）和平均粒径等参数对槲皮素脂质体制剂进行体外表征;所得值分别为86.5 ± 0.42%、76.5%和146 nm。可以得出结论，槲皮素负载的脂质体制剂实现药物在伤口区域的持续释放。
The basic objective of this study was to prepare quercetin-loaded liposomes by the thin film hydration method. The liposomal formulation was optimized using response surface methodology (RSM). A rotation speed of 75 rpm and a water bath temperature of 46 degrees C were finalized as the best for optimized drug-loaded liposomal formulation. In vitro characterization of the quercetin-loaded liposomal formulation was done through some parameters including the entrapment efficiency (EE), drug release (DR), and mean particle size; the resulting values of 86.5 +/- 0.42%, 76.5%, and146 nm were found to be standard characterized values respectively. It is concluded that quercetin-loaded liposomal formulations achieve sustained release of drug in wound areas.