Thymic size and lymphocyte restoration in patients with human immunodeficiency virus infection after 48 weeks of zidovudine, lamivudine, and ritonavir therapy
Thymic size and lymphocyte restoration in patients with human immunodeficiency virus infection after 48 weeks of zidovudine, lamivudine, and ritonavir therapy
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DOI：
10.1086/315169
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发表时间：
2000-01-01
影响因子：
6.4
通讯作者：
Lederman, MM
中科院分区：
文献类型：
--
作者：
Smith, KY;Valdez, H;Lederman, MM
人类免疫缺陷病毒（HIV）感染与循环中CD 4（+）淋巴细胞的进行性丢失有关，高效抗逆转录病毒治疗（HAART）可导致初治患者CD 4（+）T淋巴细胞的增加。（CD 45 RA（+）62 L（+））和记忆（CD 45 R 0（+）RA（-））表型，对30名HIV患者进行胸腺计算机断层扫描，以研究胸腺在细胞修复中的作用，48周HAART在治疗后2-24周，胸腺组织丰富的个体的幼稚CD 4（+）T淋巴细胞计数高于胸腺组织很少的个体。在治疗的前4周，胸腺组织丰富的个体的初始CD 4（+）细胞显著增加，这些个体也更可能经历病毒反弹，尽管血浆HIV-1 RNA的初始下降相当。这些发现表明，在HIV疾病中应用HAART后，胸腺、病毒复制和淋巴细胞恢复之间存在复杂的关系。
Human immunodeficiency virus (HIV) infection is associated with progressive loss of circulating CD4(+) lymphocytes, Treatment with highly active antiretroviral therapy (HAART) has led to increases in CD4(+) T lymphocytes of naive (CD45RA(+)62L(+)) and memory (CD45R0(+)RA(-)) phenotypes, Thymic computerized tomography scans were obtained on 30 individuals with HIV disease to investigate the role of the thymus in cellular restoration after 48 weeks of HAART. Individuals with abundant thymic tissue had higher naive CD4(+) T lymphocyte counts at weeks 2-24 after therapy than individuals with minimal thymic tissue. Individuals with abundant thymic tissue had significantly larger increases in naive CD4(+) cells during the first 4 weeks of therapy, These individuals were also more likely to experience viral rebound despite comparable initial declines in plasma HIV-1 RNA. These findings suggest that there is a complex relationship among the thymus, viral replication, and lymphocyte restoration after application of HAART in HIV disease.