EFFECT OF GAS COMPRESSION ON PULMONARY PRESSURE FLOW AND VOLUME RELATIONSHIP
EFFECT OF GAS COMPRESSION ON PULMONARY PRESSURE FLOW AND VOLUME RELATIONSHIP
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DOI：
10.1152/jappl.1966.21.6.1821
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发表时间：
1966-01-01
影响因子：
3.3
通讯作者：
SCHILDER, DP
中科院分区：
文献类型：
--
作者：
INGRAM, RH;SCHILDER, DP
在5例正常人和10例阻塞性气道疾病患者中，体积描记法测量的气体压缩和置换引起的肺容积变化（[DELTA]VL）的时间过程与呼气容积（[DELTA] V）、经肺动脉压（P）和流量（F）的时间过程同时相关。比较了基于[DELTA]V和[DELTA] VL的等体积PF关系，以及F与[DELTA]V和F与[DELTA] VL曲线。在较高压力下，在呼气VC的较低75%上，对于给定的[DELTA] VL，流量大于[DELTA] V。通过压缩气体的高压使肺体积减小的程度大于[DELTA] W所指示的。与等体积[DELTA] V PF曲线相比，等体积[DELTA] VL PF曲线的最大值定义较差。这些差异反映在F与[DELTA] VL和F与[DELTA] v曲线中。阻塞性气道疾病患者的大肺容量和高气道阻力放大了这些差异。只有体积描记法才能获得恒定肺容量下的PF关系。
The time course of lung volume change ([DELTA]VL) due to compression and displacement of gas as measured plethysmographically was simultaneously related to the time courses of expired volume ([DELTA] V), transpulmonary pressure (P) and flow (F) during vital capacities (VC) of varying effort in 5 normal subjects and 10 patients with obstructuve airway disease. Isovolume PF relationships based on [DELTA]V and [DELTA] VL were compared, as were F versus [DELTA]V and F versus [DELTA] VL curves. Over the lower 75% of the expiratory VC at higher pressures, flow was greater for a given [DELTA] VL than [DELTA] V. High pressure by compressing gas decreases lung volume more than [DELTA] W indicates. On isovolume [DELTA] VL PF curves maximal were poorly defined, as contrasted with isovolume [DELTA] V PF curves. These differences were reflected in F versus [DELTA] VL and F versus [DELTA] v curves. Large lung volumes and high airway resistance in patients with obstructive airway disease magnified these differences. PF relationships at a constant lung volume can only be obtained plethysmographically.