CIRCADIAN TIMEKEEPING IN HEALTH AND DISEASE .1. BASIC PROPERTIES OF CIRCADIAN PACEMAKERS
CIRCADIAN TIMEKEEPING IN HEALTH AND DISEASE .1. BASIC PROPERTIES OF CIRCADIAN PACEMAKERS
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DOI：
10.1056/nejm198308253090806
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发表时间：
1983-01-01
影响因子：
158.5
通讯作者：
RICHARDSON, GS
中科院分区：
文献类型：
--
作者：
MOOREEDE, MC;CZEISLER, CA;RICHARDSON, GS
在过去的十年里，对昼夜节律（大约24小时）的研究已经从生物学上的好奇心发展成为一门对临床医学有着巨大影响的科学。昼夜节律振荡器理论的同时成熟，哺乳动物昼夜节律起搏器的解剖学定义，以及相当数量的人与昼夜节律计时系统故障的识别已经形成了一个新的医学学科的基础。1昼夜节律与临床医学在两个主要方面。首先，昼夜节律性是人类生理学中如此普遍的元素，以至于它的认识需要重新评估许多临床诊断和治疗方法。
THE study of circadian (approximately 24-hour) rhythms has within the past decade evolved from a biologic curiosity to a science with enormous implications for clinical medicine. The concurrent maturation of circadian oscillator theory, the anatomic definition of circadian pacemakers in mammals, and the identification of a considerable number of persons with malfunctions of the circadian timing system have formed the basis of a new medical discipline.1Circadian rhythms relate to clinical medicine in two major ways. First, circadian rhythmicity is such a pervasive element of human physiology that its recognition has required a reassessment of many clinical diagnostic and therapeutic . . .