Efficacy of combined levonorgestrel-releasing intrauterine system with gonadotropin-releasing hormone analog for the treatment of adenomyosis.
Efficacy of combined levonorgestrel-releasing intrauterine system with gonadotropin-releasing hormone analog for the treatment of adenomyosis.
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左炔诺孕酮宫内缓释系统联合促性腺激素释放激素类似物治疗子宫腺肌病的疗效
DOI：
10.1159/000351431
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Kong B
中科院分区：
文献类型：
--
作者：
Zhang P;Song K;Li L;Yukuwa K;Kong B
目的：目的评价促性腺激素释放激素类似物（GnRHa）联合左炔诺孕酮宫内缓释系统（LNG-IUS）植入治疗子宫明显增大的子宫腺肌病患者的临床疗效。研究对象和方法：21例子宫体积大于妊娠12周的子宫腺肌病患者被招募进行研究。当超声测量子宫长度小于10 cm时，每隔28 d皮下注射GnRHa，共3-4个周期。术后3、6、12个月随访子宫体积、痛经程度、月经量等临床指标。结果：植入后12个月，月经量显著低于基线值（53.8 ± 11.7 vs. 100，p = 0.03）。植入后12个月，痛经（疼痛）程度减轻（58.2 ± 11.5 vs. 93.7 ± 0.2，p = 0.005）。植入后子宫体积也低于GnRHa前水平（276.6 ± 32.1 vs. 311.4 ± 32.3，p = 0.005）。3例患者的LNG-IUS脱落，脱落率为14%。GnRHa联合LNG-IUS植入副作用少。结论：GnRHa联合LNG-IUS治疗子宫腺肌病疗效显著。
Objectives: To evaluate the clinical outcomes of gonadotropin-releasing hormone analog (GnRHa) combined with implantation of a levonorgestrel-releasing intrauterine system (LNG-IUS) in adenomyosis patients with significantly enlarged uteruses. Subjects and Methods: Twenty-one adenomyosis patients whose uterine volumes were greater in size than at 12 weeks' gestation were recruited for the study. Subcutaneous injection of GnRHa was administrated at an interval of 28 days for a total of 3-4 cycles when uterine length was determined to be less than 10 cm by ultrasound measurement. At 3, 6 and 12 months after LNG-IUS implantation, follow-up was performed to document the clinical values such as uterine volume, degree of dysmenorrhea and menstrual flow. Results: Twelve months after implantation, the menstrual flow was significantly lower than baseline values (53.8 ± 11.7 vs. 100, p = 0.03). The degree of dysmenorrhea (pain) was relieved 12 months after implantation (58.2 ± 11.5 vs. 93.7 ± 0.2, p = 0.005). Uterine volume was also below pre-GnRHa levels after implantation (276.6 ± 32.1 vs. 311.4 ± 32.3, p = 0.005). LNG-IUS was expelled in 3 patients, giving an expulsion rate of 14%. Side effects of GnRHa combined with LNG-IUS implantation were few. Conclusion: The findings indicate that combined GnRHa and LNG-IUS treatment was efficacious in patients with enlarged adenomyosis.
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影响因子：
--
作者：
Gerris, J;Degueldre, M;Dalton, E
通讯作者：
Dalton, E
影响因子：
6.7
作者：
Vercellini, P;Frontino, G;Crosignani, PG
通讯作者：
Crosignani, PG
DOI：
10.1016/j.diii.2012.10.012
发表时间：
2013-01-01
影响因子：
--
作者：
Levy, G.;Dehaene, A.;Poncelet, E.
通讯作者：
Poncelet, E.
影响因子：
2.9
作者：
Otero-Flores, JB;Guerrero-Carreño, FJ;Vázquez-Estrada, LA
通讯作者：
Vázquez-Estrada, LA
影响因子：
2.9
作者：
Fong, YF;Singh, K
通讯作者：
Singh, K