Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris.
Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris.
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DOI：
10.1186/s40560-018-0342-4
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发表时间：
2018
影响因子：
7.1
通讯作者：
Chowdhary A
中科院分区：
文献类型：
--
作者：
Cortegiani A;Misseri G;Fasciana T;Giammanco A;Giarratano A;Chowdhary A
假丝酵母菌感染是危重病人发病和死亡的主要原因。金黄色念珠菌是一种新出现的多重耐药真菌，正在全球范围内迅速传播。自2009年首次报告以来，五大洲的许多分离物已被确定为医院相关感染的病原体。独立和同时爆发的金黄色葡萄球菌正成为医疗界和科学界关注的主要问题。此外，实验室的错误识别和多重耐药谱，在其他非白念珠菌物种中很少观察到，导致难以根除金黄色葡萄球菌感染和频繁的治疗失败。本综述的目的是对金黄色葡萄球菌的全球传播提供最新和全面的报告，重点是临床和微生物学特征，毒力和抗真菌耐药性的机制，以及现有控制、预防和治疗策略的有效性。本文的在线版本(10.1186/s405600180342-4)包含补充材料，授权用户可以使用。
Candida spp. infections are a major cause of morbidity and mortality in critically ill patients. Candida auris is an emerging multi-drug-resistant fungus that is rapidly spreading worldwide. Since the first reports in 2009, many isolates across five continents have been identified as agents of hospital-associated infections. Independent and simultaneous outbreaks of C. auris are becoming a major concern for healthcare and scientific community. Moreover, laboratory misidentification and multi-drug-resistant profiles, rarely observed for other non-albicans Candida species, result in difficult eradication and frequent therapeutic failures of C. auris infections. The aim of this review was to provide an updated and comprehensive report of the global spread of C. auris, focusing on clinical and microbiological characteristics, mechanisms of virulence and antifungal resistance, and efficacy of available control, preventive, and therapeutic strategies. The online version of this article (10.1186/s40560-018-0342-4) contains supplementary material, which is available to authorized users.
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影响因子：
11.8
作者：
Belkin A;Gazit Z;Keller N;Ben-Ami R;Wieder-Finesod A;Novikov A;Rahav G;Brosh-Nissimov T
通讯作者：
Brosh-Nissimov T
影响因子：
5.5
作者：
Bougnoux ME;Brun S;Zahar JR
通讯作者：
Zahar JR
影响因子：
4.5
作者：
Cadnum, Jennifer L.;Shaikh, Aaron A.;Donskey, Curtis J.
通讯作者：
Donskey, Curtis J.
影响因子：
38.9
作者：
Bassetti, Matteo;Righi, Elda;Tumbarello, Mario
通讯作者：
Tumbarello, Mario
影响因子：
38.9
作者：
Chakrabarti, Arunaloke;Sood, Prashant;Mendiratta, Deepak
通讯作者：
Mendiratta, Deepak