BONE MASS IN FEMALES WITH DIFFERENT THYROID-DISORDERS - INFLUENCE OF MENOPAUSAL STATUS
BONE MASS IN FEMALES WITH DIFFERENT THYROID-DISORDERS - INFLUENCE OF MENOPAUSAL STATUS
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DOI：
10.1016/s0169-6009(08)80115-8
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发表时间：
1993-04-01
期刊：
影响因子：
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通讯作者：
GIMENO, EJ
中科院分区：
文献类型：
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作者：
CAMPOSPASTOR, MM;MUNOZTORRES, M;GIMENO, EJ
本研究的目的是评估绝经前和绝经后妇女甲状腺功能状态对皮质骨和骨小梁骨密度（BMD）（g/cm 2）的影响。对照受试者用作参考人群，以根据患者数据计算Z评分。活动性甲亢患者腰椎（LS; P < 0.01）、股骨颈（FN; P <0.01）和Ward三角区（WT; P < 0.0001）的BMD较对照组降低。在绝经前妇女中，既往接受过甲状腺功能亢进治疗或在研究时接受过非TSH抑制剂量的L-甲状腺素治疗，BMD没有显著降低。绝经后甲亢缓解期妇女LS、FN和WT的BMD均显著降低（P < 0.0001）。在接受L-甲状腺素（L-T4）治疗的绝经后妇女中， LS组和WT组骨密度明显降低（P <0.01）。绝经后妇女L-T4累积剂量与FN（r =-0.688，P < 0.05）和WT（r =-0.657，P < 0.05）的BMD呈显著负相关。我们的研究结果表明，甲状腺激素对BMD的有害影响在主要由骨小梁组成的区域加重，例如，LS和WT。绝经后甲状腺激素过多的妇女是骨质疏松症的高危人群。
The aim of this study was to evaluate the effect of thyroid functional state on cortical and trabecular bone mineral density (BMD) (g/cm2) in premenopausal and postmenopausal women. Control subjects were used as a reference population to calculate Z-scores from patient data. In patients with active hyperthyroidism, BMD was reduced in lumbar spine (LS; P < 0.01), femoral neck (FN; P < 0.01) and Ward triangle (WT; P < 0.0001) in comparison with reference standards. In premenopausal women treated in the past for hyperthyroidism or treated at the time of study with L-thyroxine in non-TSH-suppressive doses, there was no significant decrease in BMD. In postmenopausal women with hyperthyroidism in remission, we found a significant decrease in BMD in LS (P < 0.01), FN (P < 0.05) and WT (P < 0.0001). In postmenopausal women treated with L-thyroxine (L-T4), there was a significant decrease in BMD in LS (P < 0.01) and WT (P < 0.01). There was a significant negative correlation between the cumulative dose of L-T4 and BMD in FN (r = -0.688, P < 0.05) and WT (r = -0.657, P < 0.05) in postmenopausal women. Our findings suggest that the deleterious effects of thyroid hormones on BMD are accentuated in areas consisting predominantly of trabecular bone, e.g., the LS and WT. Postmenopausal women subjected to excess thyroid hormone represent a population at greater risk for osteoporosis.