MicroRT - Small animal conformal irradiator
MicroRT - Small animal conformal irradiator
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DOI：
10.1118/1.2799887
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发表时间：
2007-12-01
期刊：
影响因子：
3.8
通讯作者：
Grigsby, P. W.
中科院分区：
文献类型：
--
作者：
Stojadinovic, S.;Low, D. A.;Grigsby, P. W.
设计了一种新型的小动物适形放射治疗系统：MicroRT。microRT系统集成了多模态成像、放射治疗计划和适形放射治疗，适形放射治疗利用临床Ir-192同位素高剂量率源作为放射源（远距离治疗）。基于Monte Carlo剂量分布模拟的多参数剂量计算算法用于有效和准确地计算用于治疗计划目的的剂量。一系列精确加工的钨准直器安装在一个圆柱形准直器组件上，用于提供辐射射束入口。目前的设计允许在四个波束角度下的源到目标距离范围为1-8 cm：0度（波束向下）、90度、180度和270度。将动物麻醉并置于具有内置基准标记的固定装置中，并在照射前使用计算机断层扫描、磁共振或正电子发射断层扫描仪进行扫描。治疗计划使用多达四个波束方向创建利用自定义治疗计划系统-microRTP。一个支持和精确定位动物的三轴计算机控制的平台被编程为根据microRTP计划相对于辐射束放置动物。发现microRT系统定位精度为亚毫米。辐射源通过四个导管通道之一引导，并与钨准直器对齐放置，以提供适形辐射治疗。的microRT硬件规格，治疗计划和定位系统的准确性，和一些典型的程序，可以与microRT设备进行放射生物学实验。(C)2007年美国医学物理学家协会。
A novel small animal conformal radiation therapy system has been designed and prototyped: MicroRT. The microRT system integrates multimodality imaging, radiation treatment planning, and conformal radiation therapy that utilizes a clinical Ir-192 isotope high dose rate source as the radiation source (teletherapy). A multiparameter dose calculation algorithm based on Monte Carlo dose distribution simulations is used to efficiently and accurately calculate doses for treatment planning purposes. A series of precisely machined tungsten collimators mounted onto a cylindrical collimator assembly is used to provide the radiation beam portals. The current design allows a source-to-target distance range of 1-8 cm at four beam angles: 0 degrees (beam oriented down), 90 degrees, 180 degrees, and 270 degrees. The animal is anesthetized and placed in an immobilization device with built-in fiducial markers and scanned using a computed tomography, magnetic resonance, or positron emission tomography scanner prior to irradiation. Treatment plans using up to four beam orientations are created utilizing a custom treatment planning system-microRTP. A three-axis computer-controlled stage that supports and accurately positions the animals is programmed to place the animal relative to the radiation beams according to the microRTP plan. The microRT system positioning accuracy was found to be submillimeter. The radiation source is guided through one of four catheter channels and placed in line with the tungsten collimators to deliver the conformal radiation treatment. The microRT hardware specifications, the accuracy of the treatment planning and positioning systems, and some typical procedures for radiobiological experiments that can be performed with the microRT device are presented. (C) 2007 American Association of Physicists in Medicine.