Hypoxia-inducible factor 1:: regulation by hypoxic and non-hypoxic activators
Hypoxia-inducible factor 1:: regulation by hypoxic and non-hypoxic activators
复制标题
DOI：
10.1016/j.biocel.2004.08.012
复制
发表时间：
2005-03-01
影响因子：
4
通讯作者：
Richard, DE
中科院分区：
文献类型：
--
作者：
Déry, MAC;Michaud, MD;Richard, DE
氧气供应对细胞代谢至关重要。缺氧诱导因子-1（HIF-1）是氧稳态的主要调节因子。在常氧条件下，HIF- 1被蛋白酶体迅速降解。然而，在低氧条件下，HIF-I是稳定的，并允许细胞适应低氧条件所必需的基因的激活。这些基因包括血管内皮生长因子（VEGF）、促红细胞生成素和葡萄糖转运蛋白-1。越来越多的证据表明，HIF-1还涉及需要其在常氧条件下活化的生物学功能。其中，生长因子和血管激素与这种常氧激活有关。在这篇综述中，我们将集中在缺氧和非缺氧诱导和激活HIF- 1的差异。我们还将讨论与这两种诱导途径相关的HIF-1的生物学功能.对HIF-1激活机制的清楚理解可能对癌症和血管疾病产生重大影响。(C)2004 Elsevier Ltd.保留所有权利。
Oxygen availability is crucial for cellular metabolism. Hypoxia-inducible factor 1 (HIF-1) is the major oxygen homeostasis regulator. Under normoxic conditions, HIF- 1 is rapidly degraded by the proteasome. However, under hypoxic conditions, HIF- I is stabilized and permits the activation of genes essential to cellular adaptation to low oxygen conditions. These genes include the vascular endothelial growth factor (VEGF), erythropoietin and glucose transporter-1. There is increasing evidence showing that HIF- I is also implicated in biological functions requiring its activation under normoxic conditions. Amongst others, growth factors and vascular hormones are implicated in this normoxic activation. In this review, we will focus on differences between hypoxic and non-hypoxic induction and activation of HIF- 1. We will also discuss the biological functions of HIF- I associated with these two induction pathways. The clear understanding of both HIF- I activation mechanisms could have a major impact in cancer and vascular disease. (C) 2004 Elsevier Ltd. All rights reserved.