The brainstem and thalamic lesions in dentatorubral‐pallidoluysian atrophy
The brainstem and thalamic lesions in dentatorubral‐pallidoluysian atrophy
复制标题
齿状红核-苍白路易体萎缩的脑干和丘脑病变
作者：
H. Tomiyasu;F. Yoshii;Y. Ohnuki;J. Ikeda;Y. Shinohara
我们用MRI研究了齿状体-苍白球萎缩的脑干和丘脑病变的频率和特征。在通过DNA分析确诊的15名受试者中，13人的脑桥基底有损伤，9人的中脑有损伤，5人的丘脑有损伤。病变与患者年龄呈正相关，但与神经系统特征或CAG重复次数无关。患有Machado-Joseph病或脊髓小脑共济失调1的患者没有表现出这些特征性病变。
We studied the frequency and characteristics of brain-stem and thalamic lesions in dentatorubral-pallidoluysian atrophy using MRI. Of 15 subjects diagnosed by DNA analysis, 13 had lesions in the pontine base, nine in the midbrain, and five in the thalamus. Lesions were correlated positively with the patient's age, but not with neurologic features or numbers of CAG repeats. Patients with Machado-Joseph disease or spinocerebellar ataxia 1 did not show these characteristic lesions.