Calories do not explain extension of life span by dietary restriction in Drosophila.
Calories do not explain extension of life span by dietary restriction in Drosophila.
复制标题
卡路里不能通过果蝇饮食限制来解释寿命的延长。
DOI：
10.1371/journal.pbio.0030223
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发表时间：
2005-07
期刊：
影响因子：
9.8
通讯作者：
Partridge, Linda
中科院分区：
文献类型：
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作者：
Mair, William;Piper, Matthew D W;Partridge, Linda
饮食限制（DR）延长了包括哺乳动物在内的各种生物的寿命，并且可能有共同的机制在起作用。DR通常被称为卡路里限制，因为已经表明减少卡路里，而不是饮食中的特定营养素，介导啮齿动物寿命的延长。我们在这里证明，延长寿命的DR在果蝇中是不是由于减少热量摄入。减少饮食中的酵母或糖可以降低死亡率并延长寿命，但数量与食物的卡路里含量无关，并且酵母对每卡路里的影响比糖大得多。因此，热量摄入不是该物种DR死亡率降低的关键因素。实验证据表明，特定的营养成分，而不是减少热量摄入本身，是负责延长寿命通过饮食限制在果蝇。
Dietary restriction (DR) extends life span in diverse organisms, including mammals, and common mechanisms may be at work. DR is often known as calorie restriction, because it has been suggested that reduction of calories, rather than of particular nutrients in the diet, mediates extension of life span in rodents. We here demonstrate that extension of life span by DR in Drosophila is not attributable to the reduction in calorie intake. Reduction of either dietary yeast or sugar can reduce mortality and extend life span, but by an amount that is unrelated to the calorie content of the food, and with yeast having a much greater effect per calorie than does sugar. Calorie intake is therefore not the key factor in the reduction of mortality rate by DR in this species. Experimental evidence reveals that specific nutritional components, rather than reducing calorie intake per se, are responsible for extending lifespan via dietary restriction in Drosophila melanogaster.