Prognostic factors for outcomes and complications for primary squamous cell carcinoma of the vagina treated with radiation
Prognostic factors for outcomes and complications for primary squamous cell carcinoma of the vagina treated with radiation
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DOI：
10.1016/j.ygyno.2007.01.033
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发表时间：
2007-06-01
影响因子：
4.7
通讯作者：
Kapp, Daniel S.
中科院分区：
文献类型：
--
作者：
Tran, Phuoc T.;Su, Zheng;Kapp, Daniel S.
目的.分析在一个单一机构接受放射治疗的阴道原发性鳞状细胞癌（SCCA）的治疗结果并确定预后因素。在该回顾性系列中分析了78例患者。平均特征：随访89个月;年龄65岁（范围33-99）;肿瘤大小3.8 cm（0.3-10）;治疗血红蛋白12.4 g/dl（范围8.7-14.4）;肿瘤剂量72戈伊（范围6-127）。此外，49%的研究对象曾做过子宫切除术。FIGO分期分布：I（42%）; II（29%）; III（17%）;和IVA/B（11%）。62%的患者接受了外照射（EBRT）和近距离放射治疗的联合治疗，22%的患者单独接受了EBRT治疗，13%的患者单独接受了近距离放射治疗。Kaplan-Meier（KM）5年盆腔控制、无远处转移生存率和疾病特异性生存概率：I期，83%、100%和92%; II期，76%、95%和68%; III期，62%、65%和44%; IV期，30%、18%和13%。多变量分析：分期、治疗、血红蛋白和既往子宫切除术是DSS的预后因素（p
Purpose. To analyze the results of treatment and identify prognostic factors for primary squamous cell carcinoma (SCCA) of the vagina managed with radiotherapy at a single institution.Materials and methods. Seventy-eight patients were analyzed in this retrospective series. Mean characteristics: follow-up 89 months; age 65 years (range 33-99); tumor size 3.8 cm (0.3-10); treatment hemoglobin 12.4 g/dl (range 8.7-14.4); and tumor dose 72 Gy (range 6-127). In addition, 49% of our cohort had a prior hysterectomy. The FIGO stage distribution: I (42%); II (29%); III (17%); and IVA/B (11%). Sixty-two percent of patients were treated with a combination of external beam radiation (EBRT) and brachytherapy, 22% with EBRT alone and 13% with brachytherapy alone.Results. Kaplan-Meier (KM) 5-year pelvic control, distant metastasis free survival and disease specific survival probabilities: stage I, 83%, 100%, and 92%; stage II, 76%, 95%, and 68%; stage III, 62%, 65%, and 44%; and stage IV, 30%, 18%, and 13%. On multivariate analysis: stage; treatment hemoglobin; and prior hysterectomy were prognostic for DSS (p