CeNDR, the Caenorhabditis elegans natural diversity resource
CeNDR, the Caenorhabditis elegans natural diversity resource
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DOI：
10.1093/nar/gkw893
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发表时间：
2017-01-04
影响因子：
14.9
通讯作者：
Andersen, Erik C.
中科院分区：
文献类型：
--
作者：
Cook, Daniel E.;Zdraljevic, Stefan;Andersen, Erik C.
对模式生物的研究已经对疾病的病因学和我们对进化过程的理解产生了相当多的见解。秀丽隐杆线虫是用于理解生物学的最强大的模式生物之一。然而，C.在研究自然变异如何塑造性状方面，尤其是通过使用全基因组关联（GWA）分析，线虫没有像其他模式生物那样广泛使用。在这里，我们介绍一个新平台：C.线虫自然多样性资源（CeNDR），使统计遗传学和基因组学研究的C。并将结果与人类疾病联系起来。CeNDR为研究社区提供了野生菌株，每个菌株的全基因组序列和变体数据，以及用于研究C.优雅的此外，C. elegans社区可以受益于公共地图和综合工具进行比较分析。CeNDR使用几个数据库，这些数据库通过添加新菌株、测序数据和关联映射结果而不断更新。CeNDR数据可通过http://www.elegansvariation.org免费提供的门户网站或通过应用程序编程接口访问。
Studies in model organisms have yielded considerable insights into the etiology of disease and our understanding of evolutionary processes. Caenorhabditis elegans is among the most powerful model organisms used to understand biology. However, C. elegans is not used as extensively as other model organisms to investigate how natural variation shapes traits, especially through the use of genome-wide association (GWA) analyses. Here, we introduce a new platform, the C. elegans Natural Diversity Resource (CeNDR) to enable statistical genetics and genomics studies of C. elegans and to connect the results to human disease. CeNDR provides the research community with wild strains, genome-wide sequence and variant data for every strain, and a GWA mapping portal for studying natural variation in C. elegans. Additionally, researchers outside of the C. elegans community can benefit from public mappings and integrated tools for comparative analyses. CeNDR uses several databases that are continually updated through the addition of new strains, sequencing data, and association mapping results. The CeNDR data are accessible through a freely available web portal located at http://www.elegansvariation.org or through an application programming interface.