Overweight and obesity as risk factors for atrial fibrillation or flutter: The Danish Diet, Cancer, and Health Study
Overweight and obesity as risk factors for atrial fibrillation or flutter: The Danish Diet, Cancer, and Health Study
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DOI：
10.1016/j.amjmed.2005.01.031
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发表时间：
2005-05-01
影响因子：
5.9
通讯作者：
Vestergaard, P
中科院分区：
文献类型：
--
作者：
Frost, L;Hune, LJ;Vestergaard, P
目的：我们检查了作为连续变量分析的体重指数和根据世界卫生组织标准（正常体重、超重和肥胖）分类与医院（住院患者和门诊患者）诊断心房颤动或扑动的风险之间的关联。方法：从 1993 年 12 月到 2001 年 12 月对 47 589 名参与者（22 482 名男性和 25 名女性）进行了基于人群的前瞻性队列研究。丹麦饮食、癌症和健康研究中的 107 名女性）没有既往患有心血管或内分泌疾病，基线平均年龄为 56 岁（范围 50-64 岁）。受试者在丹麦国家患者登记处和丹麦民事登记系统中接受随访。结果：在随访期间（平均 5.7 年），553 名受试者（372 名男性和 181 名女性）出现心房颤动或心房扑动。体重指数每增加一个单位，调整后的房颤或心房扑动风险比在男性中为 1.08（95% 置信区间 [Cl]：1.05 至 1.11），在女性中为 1.06（95% CI：1.03 至 1.09）。当使用正常体重作为参考时，超重导致心房颤动或扑动的调整后危险比，男性为 1.75（95% CI：1.35 至 2.27），女性为 1.39（95% CI：0.99 至 1.94）。调整后的肥胖风险比，男性为 2.35（95% Cl：1.70 至 3.25），女性为 1.99（95% Cl：1.31 至 3.02）。结论：超重和肥胖与心房颤动或扑动的诊断风险增加相关。 (c) 2005 Elsevier Inc. 保留所有权利。
PURPOSE: We examined the association between the body mass index analyzed as a continuous variable and by categorization according to World Health Organization criteria (normal weight, overweight and obesity) and the risk of a hospital (inpatient as well as outpatient) diagnosis of atrial fibrillation or flutter.METHODS: Population-based prospective cohort study conducted from December 1993 to December 2001 among 47 589 participants (22 482 men and 25 107 women) without preexisting cardiovascular or endocrine disease and with a mean age at baseline of 56 years (range 50-64 years) in the Danish Diet, Cancer, and Health Study. Subjects were followed up in the Danish National Registry of Patients and in the Danish Civil Registration System.RESULTS: During follow-up (mean, 5.7 years) atrial fibrillation or flutter developed in 553 subjects (372 men and 181 women). The adjusted hazard ratio for atrial fibrillation or flutter per unit of increase in the body mass index was 1.08 (95% confidence interval [Cl]: 1.05 to 1.11) in men and 1.06 (95% CI: 1.03 to 1.09) in women. When using normal weight as a reference, the adjusted hazard ratio for atrial fibrillation or flutter by overweight was 1.75 (95% Cl: 1.35 to 2.27) in men and 1.39 (95% CI: 0.99 to 1.94) in women. The adjusted hazard ratio by obesity was 2.35 (95% Cl: 1.70 to 3.25) in men and 1.99 (95% Cl: 1.31 to 3.02) in women.CONCLUSION: Overweight and obesity are associated with an increased risk of a diagnosis of atrial fibrillation or flutter. (c) 2005 Elsevier Inc. All rights reserved.