Flow programmed field-flow fractionation
Flow programmed field-flow fractionation
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程序流场流分离
DOI：
10.1021/ac50037a015
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发表时间：
1979
影响因子：
7.4
通讯作者：
Michel Martin
中科院分区：
文献类型：
--
作者：
J. Giddings;K. Caldwell;J. F. Moellmer;T. H. Dickinson;M. N. Myers;Michel Martin
介绍并论证了场流分级 (FFF) 中的流编程概念。结果表明，该方法可以保留或提高早期峰的分辨率，同时显着加速晚期峰的洗脱，从而提高分析速度。将流程编程与相关选项、场强编程和溶剂编程进行了简要比较。然后提出背景理论，并用于表明可以采用非常突然的速度程序，而不会过度降低后期峰的分辨率。最后，在沉降 FFF 系统中使用三种尺寸的聚苯乙烯乳胶珠说明了流量编程的实用性。柱流量（或入口压力）编程是一种已被接受但尚未广泛使用的技术，用于改善气相色谱系统中的峰间距并提高分析速度 (I)。该方法的一个缺点是，在运行的后期部分中实现的增加的流速可能会过度增加板高度，从而阻碍后期峰的分辨率。通常会以
The concept of flow programming in field-flow fractionation (FFF) Is introduced and justified. It is shown that the method can preserve or improve the resolution of early peaks and at the same time significantly hasten the elution of late peaks, thus increasing analysis speed. Flow programming is com-pared briefly to the related options, field-strength and solvent programming. The background theory is then presented, and is used to show that very abrupt velocity programs can be employed without undue degradation of resolution for late peaks. Finally, the utility of flow programming is illustrated using three sizes of polystyrene latex beads in a sedimentation FFF system.The programming of column flow (or inlet pressure) is an accepted but not very widely used technique to improve the spacing of peaks and increase the speed of analysis in gas chromatographic systems (I). One drawbackof the approach is that the increased flow rate realized in the latter parts of the run may increase the plate height excessively and thereby hinder the resolution of late peaks. One usually ends up with