Cancer prevention and therapy through the modulation of the tumor microenvironment.
Cancer prevention and therapy through the modulation of the tumor microenvironment.
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通过调节肿瘤微环境进行预防和治疗。
DOI：
10.1016/j.semcancer.2015.02.007
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发表时间：
2015-12
影响因子：
14.5
通讯作者：
Felsher DW
中科院分区：
文献类型：
--
作者：
Casey SC;Amedei A;Aquilano K;Azmi AS;Benencia F;Bhakta D;Bilsland AE;Boosani CS;Chen S;Ciriolo MR;Crawford S;Fujii H;Georgakilas AG;Guha G;Halicka D;Helferich WG;Heneberg P;Honoki K;Keith WN;Kerkar SP;Mohammed SI;Niccolai E;Nowsheen S;Vasantha Rupasinghe HP;Samadi A;Singh N;Talib WH;Venkateswaran V;Whelan RL;Yang X;Felsher DW
癌症是在体内肿瘤微环境中产生的。这种微环境既是肿瘤发生的原因也是肿瘤发生的结果。肿瘤和宿主细胞通过间接和直接的细胞相互作用动态地共同进化，在许多生物学程序中引发多尺度效应，包括细胞增殖、生长和代谢，以及血管生成、缺氧和先天和适应性免疫。在这里，我们强调了可以作为癌症预防和治疗靶点的特定生物过程。具体来说，我们描述了诸如胆固醇合成和代谢物、活性氧和缺氧、巨噬细胞激活和转化、树突状细胞的吲哚胺2,3 -双加氧酶调节、血管内皮生长因子调节血管生成、纤维化抑制、内激素和Janus激酶信号传导等靶点的抑制如何成为肿瘤发生和肿瘤微环境调节中重要的潜在联系的例子。我们还确定了治疗药物作为治疗方法，特别是天然产品，如小檗碱、白藜芦醇、洋葱素A、表没食子儿茶素没食子酸酯、染料木素、姜黄素、柚皮素、去氧rhapontigenin、胡椒碱和zerumbone，可能需要进一步研究以肿瘤微环境为目标来治疗和/或预防癌症。
Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve dynamically through indirect and direct cellular interactions, eliciting multiscale effects on many biological programs, including cellular proliferation, growth, and metabolism, as well as angiogenesis and hypoxia and innate and adapative immunity. Here we highlight specific biological processes that could be exploited as targets for the prevention and therapy of cancer. Specifically, we describe how inhibition of targets such as cholesterol synthesis and metabolites, reactive oxygen species and hypoxia, macrophage activation and conversion, indoleamine 2, 3-dioxygenase regulation of dendritic cells, vascular endothelial growth factor regulation of angiogenesis, fibrosis inhibition, endoglin, and Janus kinase signaling emerge as examples of important potential nexuses in the regulation of tumorigenesis and the tumor microenvironment that can be targeted. We have also identified therapeutic agents as approaches, in particular natural products such as berberine, resveratrol, onionin A, epigallocatechin gallate, genistein, curcumin, naringenin, desoxyrhapontigenin, piperine, and zerumbone, that may warrant further investigation to target the tumor microenvironment for the treatment and/or prevention of cancer.