Primary Cilia and Coordination of Receptor Tyrosine Kinase (RTK) and Transforming Growth Factor β (TGF-β) Signaling
Primary Cilia and Coordination of Receptor Tyrosine Kinase (RTK) and Transforming Growth Factor β (TGF-β) Signaling
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DOI：
10.1101/cshperspect.a028167
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发表时间：
2017-06-01
影响因子：
7.2
通讯作者：
Pedersen, Lotte B.
中科院分区：
文献类型：
--
作者：
Christensen, Soren T.;Morthorst, Stine K.;Pedersen, Lotte B.
自本世纪初以来，对初级纤毛的研究已经彻底改变了我们理解脊椎动物发育和组织稳态过程中细胞如何整合和组织各种信号通路的方式。初级纤毛是一种独特的感觉细胞器，可以检测细胞外环境的变化，整合并向细胞传递信号信息，调节各种细胞、发育和生理过程。许多不同的信号通路现在已经被证明依赖于初级纤毛的正常功能，而导致纤毛功能障碍的突变是被称为纤毛病的多效性疾病和综合征的根源。在这篇综述中，我们介绍了初级纤毛介导的受体酪氨酸激酶（RTK）和转化生长因子β (tgf - β)信号调节的综述。此外，我们讨论了这些途径的协调缺陷如何与纤毛病有关。
Since the beginning of the millennium, research in primary cilia has revolutionized our way of understanding how cells integrate and organize diverse signaling pathways during vertebrate development and in tissue homeostasis. Primary cilia are unique sensory organelles that detect changes in their extracellular environment and integrate and transmit signaling information to the cell to regulate various cellular, developmental, and physiological processes. Many different signaling pathways have now been shown to rely on primary cilia to function properly, and mutations that lead to ciliary dysfunction are at the root of a pleiotropic group of diseases and syndromic disorders called ciliopathies. In this review, we present an overview of primary cilia-mediated regulation of receptor tyrosine kinase (RTK) and transforming growth factor beta (TGF-beta) signaling. Further, we discuss how defects in the coordination of these pathways may be linked to ciliopathies.