Administration of opiate antagonist naloxone induces recurrence of increased jaw muscle activities related to inflammatory irritant application to rat temporomandibular joint region.
Administration of opiate antagonist naloxone induces recurrence of increased jaw muscle activities related to inflammatory irritant application to rat temporomandibular joint region.
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阿片拮抗剂纳洛酮的施用诱导与大鼠颞下颌关节区域的炎症刺激物相关的下颌肌肉活动增加的复发。
DOI：
10.1152/jn.1994.72.3.1430
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发表时间：
1994
影响因子：
2.5
通讯作者：
Hu,JW
中科院分区：
文献类型：
--
作者：
Yu,XM;Sessle,BJ;Vernon,H;Hu,JW
1. 我们最近对大鼠的研究表明，将小纤维兴奋性和炎症刺激性芥子油注射到颞下颌关节（TMJ）区域可以引起颌部肌肉肌电图（EMG）活动持续且可逆的增加和急性炎症反应。本研究的目的是测试阿片类药物机制是否参与调节芥子油引起的肌电图增加。 2.将芥子油注射到大鼠颞下颌关节区域引起下颌肌肉肌电图活动显着增加；车用矿物油则没有这样的效果。肌电图活性的增加持续长达 20 分钟，并在芥子油注射后 30 分钟恢复到控制（注射前）水平，此时给予阿片拮抗剂纳洛酮（1.3 mg/kg 静脉注射）诱导肌电图活性的显着复发。这种肌电图活性的“重新点燃”出现在纳洛酮给药后 5 至 10 分钟，并持续 10 至 20 分钟。相比之下，在颞下颌关节区域接受矿物油注射的动物中施用纳洛酮并没有“重新点燃”肌电图活性，外周作用阿片拮抗剂甲基纳洛酮或纳洛酮载体的施用也没有“重新点燃”肌电图活性。 3. 这些发现表明，阿片拮抗剂纳洛酮的应用会导致大鼠颞下颌关节区域注射芥子油反射性诱发下颌肌肉活动增加。他们认为，芥子油诱导的传入屏障激活的中枢阿片类药物抑制机制限制了诱发肌电图变化的持续时间。
1. Our recent studies in rats have demonstrated that the small-fiber excitant and inflammatory irritant mustard oil injected into the temporomandibular joint (TMJ) region can evoke a sustained and reversible increase of electromyographic (EMG) activity in jaw muscles and an acute inflammatory response. The aim of the present study was to test if opioid mechanisms are involved in modulating the EMG increase evoked by mustard oil. 2. Mustard oil injected into the rat TMJ region evoked significant increases of jaw muscle EMG activity; the vehicle mineral oil had no such effect. The increased EMG activity lasted up to 20 min, and by 30 min after the mustard oil injection had returned to control (preinjection) levels, at which time administration of the opiate antagonist naloxone (1.3 mg/kg i.v.) induced a significant recurrence of the increase in EMG activity. This "rekindling" of EMG activity appeared at 5 to 10 min after the naloxone administration and lasted for 10 to 20 min. In contrast, naloxone administration in the animals receiving mineral oil injection into the TMJ region did not "rekindle" the EMG activity, nor did the administration of the peripherally acting opiate antagonist methylnaloxone or the vehicle of naloxone. 3. These findings reveal that the application of the opiate antagonist naloxone produces a recurrence of increased jaw muscle activity reflexively evoked by mustard oil injection into the rat TMJ region. They suggest that central opioid depressive mechanisms activated by the mustard oil-induced afferent barrage limit the duration of the evoked EMG changes.