Noninvasive vascular displacement estimation for relative elastic modulus reconstruction in transversal imaging planes.
Noninvasive vascular displacement estimation for relative elastic modulus reconstruction in transversal imaging planes.
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DOI：
10.3390/s130303341
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发表时间：
2013-03-11
期刊：
影响因子：
--
通讯作者：
de Korte CL
中科院分区：
文献类型：
--
作者：
Hansen HH;Richards MS;Doyley MM;de Korte CL
动脉粥样硬化斑块破裂可引发中风或心肌梗死。富脂斑块与薄纤维帽有较高的风险比纤维斑块破裂。富脂组织和纤维组织的弹性模量不同，可以使用从血管内超声射频（RF）数据采集估计的组织位移进行重建。本研究调查了使用基于迭代2D互相关的位移估计算法在横向成像平面中对血管进行无创RF采集是否可能进行模量重建。此外，由于已知可以通过复合在各种波束转向角处估计的位移来改善位移，因此我们比较了具有复合和不具有复合的模量重建的性能。为了进行比较，模拟和实验的RF数据生成的各种血管模拟体模。重建误差小于10%，这似乎足以区分富含脂肪的纤维组织。复合优于单角度重建：各种均匀体模层的重建模量的四分位数范围约小两倍。此外，估计的横向位移是与对应于重建的模量分布的位移更好地匹配的2-3倍。因此，非侵入性的弹性模量重建是可能的横向血管横截面使用这种互相关的方法，更准确的复合。
Atherosclerotic plaque rupture can initiate stroke or myocardial infarction. Lipid-rich plaques with thin fibrous caps have a higher risk to rupture than fibrotic plaques. Elastic moduli differ for lipid-rich and fibrous tissue and can be reconstructed using tissue displacements estimated from intravascular ultrasound radiofrequency (RF) data acquisitions. This study investigated if modulus reconstruction is possible for noninvasive RF acquisitions of vessels in transverse imaging planes using an iterative 2D cross-correlation based displacement estimation algorithm. Furthermore, since it is known that displacements can be improved by compounding of displacements estimated at various beam steering angles, we compared the performance of the modulus reconstruction with and without compounding. For the comparison, simulated and experimental RF data were generated of various vessel-mimicking phantoms. Reconstruction errors were less than 10%, which seems adequate for distinguishing lipid-rich from fibrous tissue. Compounding outperformed single-angle reconstruction: the interquartile range of the reconstructed moduli for the various homogeneous phantom layers was approximately two times smaller. Additionally, the estimated lateral displacements were a factor of 2–3 better matched to the displacements corresponding to the reconstructed modulus distribution. Thus, noninvasive elastic modulus reconstruction is possible for transverse vessel cross sections using this cross-correlation method and is more accurate with compounding.
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