Serum osteoprotegerin levels and the extent of vascular calcification in haemodialysis patients
Serum osteoprotegerin levels and the extent of vascular calcification in haemodialysis patients
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DOI：
10.1093/ndt/gfh263
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发表时间：
2004-07-01
影响因子：
6.1
通讯作者：
Nihei, H
中科院分区：
文献类型：
--
作者：
Nitta, K;Akiba, T;Nihei, H
背景。骨保护素（OPG）是一种抑制破骨细胞分化和活性的糖蛋白。opg缺陷小鼠出现严重骨质疏松和内侧动脉钙化。在非尿毒症患者早期动脉粥样硬化病变中检测到OPG的表达。我们研究了血液透析患者血清OPG是否与主动脉钙化有关。对102例血液透析患者进行血清OPG测定。通过计算机断层扫描评估主动脉钙化指数（ACI）。酶联免疫吸附试验测定的血清OPG水平在ACI较高的患者中明显高于ACI较低的患者。ACI与血清OPG水平直接相关，OPG与ACI呈正相关（r = 0.483, P < 0.0001）。多元回归分析显示，血清OPG水平与主动脉钙化严重程度独立相关（P < 0.0001）。这些结果表明，血清OPG水平与血管钙化程度相关，提示OPG可能参与血液透析患者血管钙化的发展。
Background. Osteoprotegerin (OPG) is a glycoprotein that inhibits osteoclast differentiation and activity. OPG-deficient mice develop severe osteoporosis and medial arterial calcification. The expression of OPG is detected in early atherosclerotic lesions in non-uraemic patients. We examined whether serum OPG is associated with aortic calcification in haemodialysis patients.Methods. Serum OPG was measured in 102 patients who were undergoing haemodialysis. The aortic calcification index (ACI) was assessed by computed tomography scans.Results. Serum OPG level, measured by enzymelinked immunosorbent assay, was significantly greater in patients with higher ACI than in those with lower ACI. There was a direct relationship between ACI and serum OPG levels and a positive association between OPG and ACI (r = 0.483, P < 0.0001). Multiple regression analyses indicated that serum OPG levels were independently associated with the severity of aortic calcification (P < 0.0001).Conclusions. These findings show that serum OPG levels are associated with the extent of vascular calcification, suggesting that OPG may be involved in the development of vascular calcification in haemodialysis patients.