Validity of transdermal alcohol monitoring: Fixed and self-regulated dosing
Validity of transdermal alcohol monitoring: Fixed and self-regulated dosing
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DOI：
10.1111/j.1530-0277.2006.00004.x
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发表时间：
2006-01-01
影响因子：
3.2
通讯作者：
Crowley, TJ
中科院分区：
文献类型：
--
作者：
Sakai, JT;Mikulich-Gilbertson, SK;Crowley, TJ
Background: To study the validity of transdermal assessment of alcohol concentration measured by a lightweight, noninvasive device.Methods: Subjects wore a 227-g anklet that sensed transdermal alcohol concentrations (TACs) every 15 to 30 minutes, downloading results to a remote computer each day. Twenty-four subjects entered a laboratory and received a dose of 0, 0.28, or 0.56 g/kg of ethanol. Breath alcohol concentrations (BrAC) and TAC were measured every 15 to 30 minutes Twenty others [10 alcohol dependent (AD) and 10 not (NAD)] in the community who wore the anklet for 8 days kept a drinking log and provided a BrAC sample each day.Results: In the laboratory, no zero-dose subject, and every subject receiving alcohol, had alcohol-positive TACs. The device distinguished low- and high-alcohol-dosing groups using peak (t(14) = 3.37; p < 0.01) and area under the curve (t(14) = 3.42;p < 0.01) of TACs. Within dosing groups, average TAC curves were broader (right-shifted) and had lower peaks than average BrAC curves. For community participants, self-reported number of drinks (t(18)=-3.77; p < 0.01), area under the TAC curve N-9.5 = -3.56; p < 0.01), and mean TAC (t(9.9) = -3.35; p < 0.01) all significantly distinguished the AD and NAD groups. However, individual transdermal readings were not reliably quantitatively equivalent to simultaneously obtained breath results.Conclusions: Within the limits of the laboratory study, the device consistently detected consumption of approximately 2 standard drinks. On average, the device shows discriminative validity as a semiquantitative measure of alcohol consumption but individual readings often are not equivalent to simultaneous BrACs.
