Au(I)-Catalyzed Rearrangement Reaction of Propargylic Aziridine: Synthesis of Trisubstituted and Cycloalkene-Fused Pyrroles
Au(I)-Catalyzed Rearrangement Reaction of Propargylic Aziridine: Synthesis of Trisubstituted and Cycloalkene-Fused Pyrroles
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Au(I) 催化的丙炔氮丙啶重排反应：三取代和环烯稠合吡咯的合成
DOI：
10.1021/ol901649p
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发表时间：
2009-09-03
期刊：
影响因子：
5.2
通讯作者：
Zhang, Fu-Min
中科院分区：
文献类型：
--
作者：
Zhao, Xiong;Zhang, En;Zhang, Fu-Min
报道了炔丙基氮丙啶在PPh_3AuCl/AgOTf催化下的重排反应，该反应涉及一个不寻常的环化/开环/Wagner-Meerwein串联过程。产物的独特结构显示了其在合成结构多样的生物碱中的潜在应用。
A rearrangement reaction of propargylic aziridine, catalyzed by PPh3AuCl/AgOTf, forming trisubstituted and cycloalkene-fused pyrroles is described which involves an unusual tandem cyclization/ring-opening/Wagner-Meerwein process. The unique structures of the products demonstrated its potential applications for synthesizing structurally diverse alkaloids.