Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema
Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema
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DOI：
10.1038/nm1772
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发表时间：
2008-06-01
期刊：
影响因子：
82.9
通讯作者：
Eyuepoglu, Ilker Y.
中科院分区：
文献类型：
--
作者：
Savaskan, Nicolai E.;Heckel, Alexandra;Eyuepoglu, Ilker Y.
神经变性和脑水肿是人类恶性脑肿瘤的标志。在这里，我们证明体内谷氨酸转运蛋白 xCT（X-c(-) 系统，由 SLC7a11 编码）的遗传或药理学抑制可导致消除神经退行性变、减轻灶周水肿并延长生存期。这些结果表明 xCT 在神经胶质瘤诱导的神经变性和脑水肿中发挥着至关重要的作用，证实了水肿形成可能部分是瘤周细胞死亡的结果的概念。
Neurodegeneration and brain edema are hallmarks of human malignant brain tumors. Here we show that genetic or pharmacological inhibition of the glutamate transporter xCT (X-c(-) system, encoded by SLC7a11) in vivo leads to abrogated neurodegeneration, attenuated perifocal edema and prolonged survival. These results show a crucial role for xCT in glioma-induced neurodegeneration and brain edema, corroborating the concept that edema formation may be in part a consequence of peritumoral cell death.