TOPOISOMERASE-I ACTIVITY IN SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK
TOPOISOMERASE-I ACTIVITY IN SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK
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DOI：
10.1288/00005537-199511000-00010
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发表时间：
1995-11-01
期刊：
影响因子：
2.6
通讯作者：
BERGER, NA
中科院分区：
文献类型：
--
作者：
MASIN, JS;BERGER, SJ;BERGER, NA
In recent preclinical and clinical trials, topoisomerase I inhibitors have shown great promise as antitumor agents. These agents are most effective against tumors with high topoisomerase I activity. Therefore, determining topoisomerase I activity in advance may predict response to topoisomerase I inhibitors.Squamous cell carcinoma of the head and neck and normal tissue samples were obtained from 12 patients, Cellular extracts were prepared, and topoisomerase I activity assays were performed. The results suggest that topoisomerase I activity in squamous cell carcinoma of the head and neck is increased approximately sixtyfold compared to normal tissue.Increased activity often correlates with clinical responsiveness; these results predict that topoisomerase I inhibitors should be effective and selective against squamous cell carcinoma of the head and neck.
