Volumetric Prefrontal Cortex Alterations in Patients With Alcohol Dependence and the Involvement of Self-Control
Volumetric Prefrontal Cortex Alterations in Patients With Alcohol Dependence and the Involvement of Self-Control
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DOI：
10.1111/acer.14211
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发表时间：
2019-11
期刊：
影响因子：
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通讯作者：
A. Rosenthal;A. Beck;E. Zois;S. Vollstädt-Klein;H. Walter;F. Kiefer;F. Lohoff;K. Charlet
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文献类型：
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作者：
A. Rosenthal;A. Beck;E. Zois;S. Vollstädt-Klein;H. Walter;F. Kiefer;F. Lohoff;K. Charlet
背景：自我控制的各个方面，例如感觉寻求和冲动控制受损，与酒精依赖（ALC）有关。相反，感觉寻求被认为在与压力相关的精神病理学中可能具有保护作用。因此，我们检查了 ALC 患者的灰质 (GM) 形态，重点关注与自我控制相关的前额叶区域的差异。此外，我们还考虑了 ALC 患者终生酒精摄入量在自我控制措施和皮质结构方面的差异。方法：通过基于体素的形态测量 (VBM)，重点关注前额叶先验定义的感兴趣区域，我们评估了一组 62 名戒毒 ALC 患者和 62 名健康对照 (HC)。 ALC 患者随后被分为高消耗者 (n = 9) 和低消耗者 (n = 53)。通过使用巴拉特冲动量表和感觉寻求量表来评估自我控制。结果：与 HC 相比，ALC 的双侧额中回（MFG）、右侧内侧前额叶皮质以及右侧前扣带回的 GM 体积显着减少。与低消耗者相比，高消耗 ALC 的右眶额皮质 GM 较小，感觉寻求得分也较低。在低消耗 ALC 中，右侧 MFG-GM 与感觉寻求程度呈正相关；特别是，较大的 MFG-GM 与更大的刺激和冒险追求相关。结论：因此，我们的研究结果 (i) 表明与自我控制相关的前额叶区域 GM 体积不足，(ii) 可能会加剧 ALC 患者的表型差异，并强调制定个体化治疗方案的重要性。
Background: Aspects of self-control such as sensation seeking and impaired impulse control have been implicated in alcohol dependence (ALC). Conversely, sensation seeking has been ascribed a possible protective role in stress-related psychopathologies. We therefore examined gray matter (GM) morphology in individuals with ALC, focusing on differences in prefrontal regions that have been associated with self-control. Additionally, we accounted for differences in lifetime alcohol intake regarding self-control measures and cortical structures in ALC patients. Methods: With voxel-based morphometry (VBM) focusing on prefrontal a priori defined regions of interest, we assessed a group of 62 detoxified ALC patients and 62 healthy controls (HC). ALC patients were subsequently divided into high (n = 9) and low consumers (n = 53). Self-control was assessed by use of the Barratt Impulsiveness Scale and the Sensation Seeking Scale. Results: Compared to HC, ALC had significantly less GM volume in bilateral middle frontal gyrus (MFG) and right medial prefrontal cortex as well as in the right anterior cingulate. High-consuming ALC showed smaller GM in right orbitofrontal cortex as well as lower sensation seeking scores than low consumers. In low-consuming ALC, right MFG-GM was positively associated with magnitude of sensation seeking; particularly, larger MFG-GM correlated with greater thrill and adventure seeking. Conclusion: Thus, our findings (i) indicate deficient GM volume in prefrontal areas related to self-control and (ii) might accentuate the phenotypic divergence of ALC patients and emphasize the importance of the development of individual treatment options.