Mast Cells as an Indicator and Prognostic Marker in Molecular Subtypes of Breast Cancer
Mast Cells as an Indicator and Prognostic Marker in Molecular Subtypes of Breast Cancer
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DOI：
10.21873/invivo.11534
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发表时间：
2019-05-01
期刊：
影响因子：
2.3
通讯作者：
Raica, Marius
中科院分区：
文献类型：
--
作者：
Carpenco, Ecaterina;Ceausu, Raluca Amalia;Raica, Marius
背景/目的：肥大细胞（MC）是肿瘤微环境中最有争议的非恶性成分。我们的目的是研究MCs密度和分布（肿瘤内MCit与肿瘤周围MCpt）与肿瘤分级和分子亚型的关系。材料与方法：采用MCs类胰蛋白酶免疫组化法对80例乳腺癌进行检测。结果：对于Luminal A肿瘤，MCit和孕激素受体（PR）之间检测到部分相关性（p=0.005）。管腔型B肿瘤显示MCpt与年龄（p=0.009）、雌激素受体（ER）（p=0.017）和PR（p=0.035）之间存在显著相关性。MCit和MCpt在该亚型（p=0.002）和三阴性乳腺癌（p=0.002）中密切相关。在HER 2亚型中，MCpt肿瘤与HER 2显著相关（p=0.044）。在G2肿瘤中，MCpt与ER（p=0.015）和PR（p=0.038）相关，而在G3肿瘤中，ER与MCit（p=0.009）和MCpt（p=0.000487）肿瘤相关。结论：MCs动力学受激素受体和HER 2状态的强烈影响。MCit在侵袭性肿瘤类型中增加，是一个更差的预后因素。
Background/Aim: Mast cells (MCs) represent the most controversial non-malignant element of the tumor microenvironment. Our aim was to study how MCs density and distribution (intratumoral-MCit versus peritumoral-MCpt) relate to tumor grade and molecular subtypes. Materials and Methods: MCs tryptase immunohistochemistry was performed on 80 cases of breast carcinomas. Results: For Luminal A tumors, a partial correlation was detected between MCit and progesterone receptor (PR) (p=0.005). Luminal B tumors showed a significant correlation between MCpt and age (p=0.009), estrogen receptor (ER) (p=0.017) and PR (p=0.035). MCit and MCpt were strongly interrelated in this subtype (p=0.002) and in triple-negative breast cancers (p=0.002). In HER2 subtype, MCpt tumors were significantly correlated with HER2 (p=0.044). In G2 tumors, MCpt correlated with ER (p=0.015) and PR (p=0.038) while in G3 tumors ER correlated with both MCit (p=0.009) and MCpt (p=0.000487) tumors. Conclusion: MCs dynamics are strongly influenced by hormone receptors and HER2 status. MCit increased in aggressive tumor types and is a worse prognostic factor.