Escalation of methamphetamine self-administration in adolescent and adult rats
Escalation of methamphetamine self-administration in adolescent and adult rats
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DOI：
10.1016/j.drugalcdep.2012.01.004
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发表时间：
2012-07-01
影响因子：
4.2
通讯作者：
Carroll, Marilyn E.
中科院分区：
文献类型：
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作者：
Anker, Justin J.;Baron, Thomas R.;Carroll, Marilyn E.
背景：甲基苯丙胺 (METH) 的使用在过去 10 年中大幅增加，并造成严重的健康问题，特别是对年轻人来说。药物滥用主要始于青春期，此时不加抑制、过量吸毒是常见现象；因此，了解这一关键时期成瘾的发展模式是预防成瘾的重要一步。在本研究中，使用暴饮暴食（即升级）的大鼠模型检查了年龄对冰毒滥用脆弱性的影响。方法：比较青少年和成年大鼠短期（ShA，2小时）和长期（LgA，6小时）自我施用冰毒的情况。在出生后 (PN) 第 23 天（青少年）和第 90 天（成人），对大鼠进行静脉注射。导管并接受训练，在 2 小时的疗程中按压杠杆以输注冰毒 (0.05 毫克/公斤)。一旦大鼠达到稳定的 METH 自我给药率，将它们分为 ShA 组或 LgA 组，并允许再自我给药 15 天。 结果：结果表明，在 LgA 条件下，青春期大鼠比成年大鼠获得了明显更多的输注，但在 ShA 期间各年龄组没有差异。在 LgA 条件下进行的 15 天测试中，青少年（而非成年人）的 METH 自我给药也显着增加（即升级）。进一(C) 2012 Elsevier Ireland Ltd. 保留所有权利。
Background: Methamphetamine (METH) use has increased substantially in the last 10 years and poses a serious health concern, especially for young populations. Drug abuse primarily begins during adolescence, when uninhibited and excessive and drug intake is a common occurrence; thus, understanding the developmental patterns of addiction during this critical period is an essential step in its prevention. In the present study, the effect of age on the vulnerability to METH abuse was examined using a rat model of bingeing (i.e., escalation).Methods: Adolescent and adult rats were compared during short (ShA, 2-h) and long-access (LgA, 6-h) to METH self-administration. On postnatal (PN) days 23 (adolescents) and 90 (adults), rats were implanted with i.v. catheters and trained to lever press for infusions of METH (0.05 mg/kg) during 2-h sessions. Once the rats reached a steady rate of METH self-administration, they were divided into ShA or LgA groups and allowed to self-administer METH for 15 additional days.Results: Results indicated that adolescent rats earned significantly more infusions than adults under the LgA condition, but the age groups did not differ during ShA. Adolescents, but not adults, also significantly increased (i.e., escalated) METH self-administration across the 15 days of testing under the LgA condition. Further analysis indicated excessive responding during infusions in the LgA METH-exposed adolescents compared to the other groups, suggesting elevated impulsivity or motivation for drug.Conclusion: These results demonstrate that adolescents are more vulnerable to the escalation of METH than adults during LgA. (C) 2012 Elsevier Ireland Ltd. All rights reserved.