Hippocampal volume reduction in major depression
Hippocampal volume reduction in major depression
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DOI：
10.1176/ajp.157.1.115
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发表时间：
2000-01-01
影响因子：
17.7
通讯作者：
Charney, DS
中科院分区：
文献类型：
--
作者：
Bremner, JD;Narayan, M;Charney, DS
目的：抑郁症患者体内糖皮质激素水平的升高被认为与海马体的损伤有关，海马体是一个与学习和记忆有关的大脑区域。本研究的目的是测量抑郁症患者的海马体积。方法：采用磁共振成像测量16例抑郁症缓解期患者和16例病例匹配的非抑郁对照组的海马体积。结果如下：抑郁症患者的左海马体积比对照组小19%，具有统计学意义，而对照组的比较区域（杏仁核、尾状核、额叶和颞叶）或全脑体积均不较小。在控制了大脑大小、酒精暴露、年龄和教育程度后，这些发现是有意义的。结论：这些发现与抑郁症患者左侧海马体积较小相一致。
Objective: Elevated levels of glucocorticoids in depression have been hypothesized to be associated with damage to the hippocampus, a brain area involved in learning and memory. The purpose of this study was to measure hippocampal volume in patients with depression. Method: Magnetic resonance imaging was used to measure the volume of the hippocampus in 16 patients with major depression in remission and 16 case-matched nondepressed comparison subjects. Results: Patients with depression had a statistically significant 19% smaller left hippocampal volume than comparison subjects, without smaller volumes of comparison regions (amygdala, caudate, frontal lobe, and temporal lobe) or whole brain volume. The findings were significant after brain size, alcohol exposure, age, and education were controlled for. Conclusions: These findings are consistent with smaller left hippocampal volume in depression.