Antispasmodic effects and toxicity of n-ethyl-3-piperidyldiphenylacetate hydrochloride (JB-305) with special reference to its action on the sphincter of Oddi of the dog.
Antispasmodic effects and toxicity of n-ethyl-3-piperidyldiphenylacetate hydrochloride (JB-305) with special reference to its action on the sphincter of Oddi of the dog.
复制标题
N-乙基-3-哌啶基二苯乙酸盐酸盐（JB-305）的解痉作用和毒性，特别是其对狗奥迪括约肌的作用。
DOI：
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发表时间：
1952
影响因子：
3.5
通讯作者：
H. Beckman
中科院分区：
文献类型：
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作者：
J. Y. Chen;H. Beckman
1. 描述了一种令人满意的原位记录狗Oddi括约肌实际活动的方法。2. 按当量剂量计算，4毫克/千克。静脉注射时，JB-305 （n -乙基-3-哌啶基-二苯乙酸酯HCl）对Oddi括约肌、十二指肠和输尿管的抗痉挛作用至少与曲森汀和罂粟碱一样有效，而且毒性并不比曲森汀和罂粟碱大。3. 在有效的抗痉挛剂量下，在总共46只狗身上观察到的JB-305相对没有任何明显的不良副作用。4. 对小鼠的毒性研究表明，JB-305的毒性并不比Trasentine大。
1. A satisfactory method for recording in situ the actual activity of the sphincter of Oddi of the dog is described. 2. On an equivalent dose basis, 4 mgm./kgm. intravenously, JB-305 (N-ethyl-3-piperidyl-diphenylacetate HCl) appears to be at least as active and no more toxic an antispasmodic agent than Trasentine and papaverine on the sphincter of Oddi, duodenum and apparently also on the ureter. 3. In effective antispasmodic doses, JB-305 is relatively free of any appreciable undesirable side-effects as observed in a total of 46 dogs. 4. Toxicity studies in mice revealed that JB-305 appears definitely no more toxic than Trasentine.