The Association Between Glaucoma, Anxiety, and Depression in a Large Population
The Association Between Glaucoma, Anxiety, and Depression in a Large Population
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DOI：
10.1016/j.ajo.2017.07.021
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发表时间：
2017-11-01
影响因子：
4.2
通讯作者：
Davis, Richard Marc
中科院分区：
文献类型：
--
作者：
Zhang, Xinxin;Olson, Daniel James;Davis, Richard Marc
目的：探讨青光眼与焦虑、抑郁的关系。设计：回顾性病例对照研究。方法：设置：北卡罗来纳大学医院和门诊诊所。研究人群：包括2008年7月1日至2015年10月1日期间所有年龄在18岁以上的患者。观察程序：使用国际疾病分类代码识别青光眼病例，以及焦虑和抑郁病例。结果测量：计算青光眼、焦虑和抑郁的比值比（OR）。按年龄、性别分别计算以上诊断的OR值。结果：共筛查4 439 518例患者，其中青光眼11 234例（0.3%），焦虑96 527例（2.2%），抑郁103 476例（2.3%）。青光眼和焦虑的校正OR为10.6(95%可信区间[CI] 10.0-11.0)，青光眼和抑郁的校正OR为12.3（95%可信区间[CI] 11.8-12.9）。青光眼伴发焦虑和抑郁的可能性不随年龄变化（P = 0.088, P = 0.736）。结论：青光眼与焦虑、抑郁均有显著相关性。(C) 2017爱思唯尔公司版权所有。)
PURPOSE: To investigate the association between glaucoma and each of anxiety and depression.DESIGN: Retrospective case-control study.METHODS: SETTINGS: University of North Carolina hospitals and outpatient clinics. STUDY POPULATION: All patients over the age of 18 years seen between July 1, 2008 and October 1, 2015 were included. OBSERVATION PROCEDURE: International Classification of Diseases codes were used to identify cases of glaucoma, as well as anxiety and depression. OUTCOME MEASURE: Odds ratios (OR) were calculated for glaucoma and each of anxiety and depression. OR were also calculated for above diagnoses separated by age group and sex.RESULTS: A total of 4 439 518 patients were screened, of which 11 234 (0.3%) have glaucoma, 96 527 (2.2%) have anxiety, and 103 476 (2.3%) have depression. The adjusted OR was 10.6 (95% confidence interval [CI] 10.0-11.0) for glaucoma and anxiety and 12.3 (95% CI 11.8-12.9) for glaucoma and depression. The likelihood of having anxiety and depression along with glaucoma did not change with age (P = .088, P = .736).CONCLUSION: There was a statistically significant association between glaucoma and each of anxiety and depression. (C) 2017 Elsevier Inc. All rights reserved.)