The role of lifetime anxiety history in the course of bipolar spectrum disorders.
The role of lifetime anxiety history in the course of bipolar spectrum disorders.
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终生焦虑史在双相谱系障碍病程中的作用。
DOI：
10.1016/j.psychres.2018.03.087
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发表时间：
2018
影响因子：
11.3
通讯作者：
Alloy,LaurenB
中科院分区：
文献类型：
--
作者：
Titone,MadisonK;Freed,RachelD;O'Garro-Moore,JaredK;Gepty,Andrew;Ng,TommyH;Stange,JonathanP;Abramson,LynY;Alloy,LaurenB
双相型谱系障碍（BSD）患者经常符合共病焦虑障碍的标准，焦虑可能是BSD病因和病程的重要因素。目前的研究探讨了终身焦虑症与前瞻性躁狂/轻躁狂与重性抑郁发作的关系。参与者是244名患有轻度BSD的年轻人（17-26岁）（即，双极-II、循环性心境、BD-NOS）。首先，双变量分析评估了有和没有DSM-IV焦虑诊断的参与者之间基线临床特征的差异。第二，负二项回归分析测试是否终生焦虑预测躁狂/轻躁狂或严重抑郁发作的数量在研究期间发展。第三，生存分析评估是否终生焦虑预测躁狂/轻躁狂和重性抑郁发作的时间。结果表明，焦虑史与基线时更严重的疾病相关。在随访中，焦虑病史预测躁狂/轻躁狂发作较少，但不能预测重性抑郁发作的次数。焦虑病史也与躁狂/轻躁狂发作的时间较长相关，但与抑郁发作的时间较短相关。研究结果证实了过去的研究，涉及焦虑症的显着影响的过程中的BSD。此外，结果扩展了先前的研究，表明焦虑症可能与疾病的躁狂/轻躁狂阶段减少有关。
Individuals with bipolar spectrum disorder (BSD) frequently meet criteria for comorbid anxiety disorders, and anxiety may be an important factor in the etiology and course of BSDs. The current study examined the association of lifetime anxiety disorders with prospective manic/hypomanic versus major depressive episodes. Participants were 244 young adults (aged 17–26) with milder forms of BSDs (i.e., bipolar-II, cyclothymia, BD-NOS). First, bivariate analyses assessed differences in baseline clinical characteristics between participants with and withoutDSM-IVanxiety diagnoses. Second, negative binomial regression analyses tested whether lifetime anxiety predicted number of manic/hypomanic or major depressive episodes developed during the study. Third, survival analyses evaluated whether lifetime anxiety predicted time to onset of manic/hypomanic and major depressive episodes. Results indicated that anxiety history was associated with greater illness severity at baseline. Over follow-up, anxiety history predicted fewer manic/hypomanic episodes, but did not predict number of major depressive episodes. Anxiety history also was associated with longer time to onset of manic/hypomanic episodes, but shorter time to onset of depressive episodes. Findings corroborate past studies implicating anxiety disorders as salient influences on the course of BSDs. Moreover, results extend prior research by indicating that anxiety disorders may be linked with reduced manic/hypomanic phases of illness.