Dammarane-type glycosides from steamed notoginseng
Dammarane-type glycosides from steamed notoginseng
复制标题
DOI：
10.1021/jf073000s
复制
发表时间：
2008-03-12
影响因子：
6.1
通讯作者：
Yang, Chong-Ren
中科院分区：
文献类型：
--
作者：
Liao, Peng-Ying;Wang, Dong;Yang, Chong-Ren
三七是五加科植物三七（Panax notoginseng (Burk.) F.H. Chen）的根，是一种中药，因其药理活性不同，有生用和炮制两种形式。对蒸三七进行详细的化学研究，分离出 27 种达玛烷型三萜类化合物 (1-27)，其中包括 4 种新苷，即三七皂苷 ST-1-ST-3 和 ST-5 (1-4)，以及其他 3 种已知化合物。在这些新化合物中，1-3 个具有新的苷元。在对其一维和二维核磁共振谱和化学反应进行详细分析的基础上，阐明了它们的结构。已知化合物高丽参皂苷-R-1(19)、野参皂苷D(20)、6''-O-乙酰人参皂苷Rg(3)(24)和3β,6α,12β-三羟蛤蜊-20(21),24-二烯(25)是首次从三七中分离得到。
Notoginseng, the root of Panax notoginseng (Burk.) F.H. Chen (Araliaceae), is a Chinese traditional medicine, which is used in both raw and processed forms due to their different pharmacological activities. Detailed chemical investigation on steamed notoginseng led to the isolation of 27 dammarane-type triterpenoids (1-27), including 4 new glycosides, namely, notoginsenosides ST-1-ST-3 and ST-5 (1-4), in addition to 3 other known compounds. Of the new compounds, 1-3 possess new aglycones. Their structures were elucidated on the basis of detailed analyses of their 1 D and 2D NMR spectra and chemical reactions. The known compounds, koryoginsenoside-R-1 (19), yesanchinoside D (20), 6 ''-O-acetylginsenoside Rg(3) (24), and 3 beta,6 alpha,12 beta-trihyclroxyclammar-20(21),24-diene (25), were isolated from notoginseng for the first time.