D-penicillamine prevents collagen accumulation in lungs of rats given bleomycin.
D-penicillamine prevents collagen accumulation in lungs of rats given bleomycin.
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DOI：
10.1378/chest.89.3_supplement.153s
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发表时间：
1986-03
期刊：
影响因子：
9.6
通讯作者：
L. Geismar;S. Hennessey;K. Reiser;J. Last
中科院分区：
文献类型：
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作者：
L. Geismar;S. Hennessey;K. Reiser;J. Last
肺纤维化是对各种损伤的终末期反应。临床表现为肺容量减少、肺顺应性降低和气体交换异常，最终导致严重残疾。在研究人类肺纤维化中存在许多固有的困难。起始事件可能未知（如某些病因不明的间质性纤维化），即使已确定特定病因，也可能难以获得准确的暴露数据。在病程早期使用氧疗和药物、吸烟、并发疾病和遗传变异都使纤维化的评估复杂化。由于同样的原因，对药物干预效果的研究也同样困难。此外，可能无法在疾病的最早阶段尝试干预。
Pulmonary fibrosis is an end-stage response to various injuries. The clinical picture is one of diminished lung volumes, decreased lung compliance, and abnormal gas exchange, resulting ultimately in severe disability. There are many difficulties inherent in studying pulmonary fibrosis in humans. The initiating events may be unknown (as in some of the interstitial fibroses of unknown etiology), Even if a specific etiologic agent has been identified, it may be difficult to obtain accurate exposure data. The use of oxygen therapy and drugs early in the course of the disease, smoking, intercurrent disease, and genetic variability all serve to complicate evaluation of fibrogenesis. Study of the effects of pharmacologic intervention is equally difficult for the same reasons. In addition, it may not be possible to attempt intervention at the earliest stages of the disease.