Circulating PD-L1 in NSCLC patients and the correlation between the level of PD-L1 expression and the clinical characteristics.
Circulating PD-L1 in NSCLC patients and the correlation between the level of PD-L1 expression and the clinical characteristics.
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DOI：
10.1111/1759-7714.12247
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发表时间：
2015-07
期刊：
影响因子：
2.9
通讯作者：
Fang J
中科院分区：
文献类型：
--
作者：
Zhang J;Gao J;Li Y;Nie J;Dai L;Hu W;Chen X;Han J;Ma X;Tian G;Wu D;Shen L;Fang J
程序性细胞死亡-1/程序性细胞死亡-1配体（PD-1/PD-L1）通路在肿瘤逃避中起着至关重要的作用。本研究评估了晚期非小细胞肺癌（NSCLC）患者循环PD-L1表达与临床特征之间的相关性。研究对象为北京肿瘤医院收治的109例晚期NSCLC患者和65例健康体检者。采用酶联免疫吸附试验检测循环PD-L1表达。分析PD-L1表达水平与临床病理特征及预后的关系。PD-L1在晚期NSCLC患者中的表达明显高于健康对照组（P < 0.001）。PD-L1的表达与腹腔脏器转移显著相关（P = 0.004）。PD-L1高表达患者的预后比低表达患者差（18.7 vs.26.8个月，P < 0.001）。PD-L1在晚期NSCLC患者中升高，可能在肿瘤免疫逃避和患者预后中发挥重要作用。
The programmed cell death-1/programmed cell death-1 ligand (PD-1/PD-L1) pathway plays a crucial role in tumor evasion. This study evaluated the association between circulating PD-L1 expression and clinical characteristics in patients with advanced non-small cell lung cancer (NSCLC). A total of 109 advanced NSCLC and 65 healthy patients from the Beijng Cancer Hospital were enrolled in the study. Circulating PD-L1 expression was tested by enzyme-linked immunosorbent assay. The associations between the level of PD-L1 expression and clinicopathologic features and prognosis were statistically analyzed. The expression of PD-L1 in advanced NSCLC patients was significantly upregulated compared with the healthy control (P < 0.001). The expression of PD-L1 was significantly correlated with abdominal organ metastasis (P = 0.004). A high PD-L1 expression had a worse prognosis than a low expression in patients (18.7 vs. 26.8 month, P < 0.001). PD-L1 was elevated in advanced NSCLC patients and may play an important role in tumor immune evasion and patient prognosis.