Risk for bipolar disorder is associated with face-processing deficits across emotions.
Risk for bipolar disorder is associated with face-processing deficits across emotions.
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DOI：
10.1097/chi.0b013e318188832e
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发表时间：
2008-12
影响因子：
13.3
通讯作者：
Leibenluft E
中科院分区：
文献类型：
--
作者：
Brotman MA;Skup M;Rich BA;Blair KS;Pine DS;Blair JR;Leibenluft E
健性双相情感障碍（BD）青少年在面部情绪标签上存在缺陷，这种缺陷存在于多种情绪中。最近的研究表明，有双相障碍家族风险但没有情绪障碍史的年轻人，也有面部情绪标签缺陷，这表明这种损伤可能是双相障碍的一种内表型。目前尚不清楚，这种缺陷在高危青年中是否存在于所有情绪中，或者这种损伤最初表现为情绪特异性功能障碍，然后随着双相障碍症状的显现而扩展到其他情绪。37名儿童双相障碍患者，25名未受影响的双相障碍一级亲属儿童，以及36名典型发展的青少年进行了情绪表达多变形任务，这是一项计算机行为任务，显示从100%中性到100%情绪表达的面部情绪等级（快乐，惊讶，恐惧，悲伤，愤怒，厌恶）。协方差的重复测量分析显示，与健康青年相比，患者和高危青年需要更强烈的情绪信息来识别和正确标记面部情绪。双相障碍患者和高危青年之间没有差异。群体情绪交互作用不显著，表明群体效应不受面部情绪的影响。有双相障碍风险的青少年在面部情绪识别方面表现出非特异性缺陷，与患者相似。需要进一步的研究来确定这些缺陷是否符合内表型的所有标准。
Euthymic bipolar disorder (BD) youths have a deficit in face emotion labeling that is present across multiple emotions. Recent research indicates that youths at familial risk for BD, but without a history of mood disorder, also have a deficit in face emotion labeling, suggesting that such impairments may be an endophenotype for BD. It is unclear if this deficit in at-risk youths is present across all emotions or if the impairment presents initially as an emotion-specific dysfunction that then generalizes to other emotions as the symptoms of BD become manifest. 37 patients with pediatric BD, 25 unaffected children with a first-degree relative with BD, and 36 typically developing youths were administered the Emotional Expression Multimorph Task, a computerized behavioral task which presents gradations of facial emotions from 100% neutrality to 100% emotional expression (happiness, surprise, fear, sadness, anger, disgust). Repeated measures analysis of covariance revealed that, compared to healthy youths, patients and at-risk youths required significantly more intense emotional information to identify and correctly label face emotions. Patients with BD and at-risk youths did not differ from each other. Group-by-emotion interactions were not significant, indicating that the group effects did not differ based on the facial emotion. Youths at risk for BD demonstrate non-specific deficits in face emotion recognition, similar to patients with the illness. Further research is needed to determine if such deficits meet all criteria for an endophenotype.