ACTIVATION OF THE DENTATE GYRUS BY PENTYLENETETRAZOL EVOKED SEIZURES INDUCES MOSSY FIBER SYNAPTIC REORGANIZATION
ACTIVATION OF THE DENTATE GYRUS BY PENTYLENETETRAZOL EVOKED SEIZURES INDUCES MOSSY FIBER SYNAPTIC REORGANIZATION
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DOI：
10.1016/0006-8993(92)91316-7
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发表时间：
1992-10-16
期刊：
影响因子：
2.9
通讯作者：
SUTULA, TP
中科院分区：
文献类型：
--
作者：
GOLARAI, G;CAVAZOS, JE;SUTULA, TP
电刺激大鼠边缘系统诱发的点燃性癫痫发作可诱导齿状回苔藓纤维通路的出芽和突触重组。为了研究由不同方法诱发的癫痫发作是否也诱导该通路的重组，在全身给予戊四氮（一种减少Cl-介导的GABA能抑制的化学惊厥剂）后，用Timm组织化学检查DG中苔藓纤维末端的分布。亚惊厥剂量的戊四氮（24 mg/kg i. p.）不伴有DG的电图癫痫发作，也不诱导苔藓纤维发芽。全身强直阵挛性癫痫发作诱发的PTZ（24 mg/kg i. p.）始终伴随着电图癫痫发作活动的DG，并诱导发芽和突触重组的苔藓纤维通路。结果表明，戊四氮诱发的反复全身性强直-阵挛性癫痫发作诱发苔藓纤维突触重组时，发作性电图放电激活DG的电路。
Kindled seizures evoked by electrical stimulation of limbic pathways in the rat induce sprouting and synaptic reorganization of the mossy fiber pathway in the dentate gyrus (DG). To investigate whether seizures evoked by different methods also induce reorganization of this pathway, the distribution of mossy fiber terminals in the DG was examined with Timm histochemistry after systemic administration of pentylenetetrazol, a chemoconvulsant that reduces Cl- mediated GABAergic inhibition. Myoclonic seizures evoked by subconvulsant doses of pentylenetetrazol (24 mg/kg i.p.) were not accompanied by electrographic seizures in the DG, and did not induce mossy fiber sprouting. Generalized tonic-clonic seizures evoked by repeated administration of PTZ (24 mg/kg i.p.) were consistently accompanied by electrographic seizure activity in the DG, and induced sprouting and synaptic reorganization of the mossy fiber pathway. The results demonstrated that repeated generalized tonic-clonic seizures evoked by pentylenetetrazol induced mossy fiber synaptic reorganization when ictal electrographic discharges activated the circuitry of the DG.