X-ray phase contrast imaging of biological specimens with femtosecond pulses of betatron radiation from a compact laser plasma wakefield accelerator
X-ray phase contrast imaging of biological specimens with femtosecond pulses of betatron radiation from a compact laser plasma wakefield accelerator
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DOI：
10.1063/1.3627216
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发表时间：
2011-08-29
影响因子：
4
通讯作者：
Yanovsky, V.
中科院分区：
文献类型：
--
作者：
Kneip, S.;McGuffey, C.;Yanovsky, V.
我们证明了来自最近展示的明亮的、超快的、相干的同步辐射桌面源的X射线[Kneip等人，NAT。太棒了。6,980(2010)]可应用于生物样品的相衬成像。我们的方案基于将高功率短脉冲激光聚焦在稀薄的气体射流中，建立一个等离子体尾波场加速器，该加速器类似于传统的同步加速器，但在厘米级而不是几十米级上加速和摆动电子。我们使用该方案记录了四条鱼、蜻蜓和黄色夹克的吸收和相衬图像，特别是强调了利用简单的相衬成像传播技术可以实现的对比度增强。相干和超快脉冲持续时间将使生物力学的各个方面的研究成为可能。(C)2011年美国物理研究所。[DOI：10.1063/1.3627216]
We show that x-rays from a recently demonstrated table top source of bright, ultrafast, coherent synchrotron radiation [Kneip et al., Nat. Phys. 6, 980 (2010)] can be applied to phase contrast imaging of biological specimens. Our scheme is based on focusing a high power short pulse laser in a tenuous gas jet, setting up a plasma wakefield accelerator that accelerates and wiggles electrons analogously to a conventional synchrotron, but on the centimeter rather than tens of meter scale. We use the scheme to record absorption and phase contrast images of a tetra fish, damselfly and yellow jacket, in particular highlighting the contrast enhancement achievable with the simple propagation technique of phase contrast imaging. Coherence and ultrafast pulse duration will allow for the study of various aspects of biomechanics. (C) 2011 American Institute of Physics. [doi:10.1063/1.3627216]