Small Cell (Neuroendocrine) Carcinoma of the Prostate: Etiology, Diagnosis, Prognosis, and Therapeutic Implications-A Retrospective Study of 30 Patients From the Rare Cancer Network
Small Cell (Neuroendocrine) Carcinoma of the Prostate: Etiology, Diagnosis, Prognosis, and Therapeutic Implications-A Retrospective Study of 30 Patients From the Rare Cancer Network
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DOI：
10.1097/maj.0b013e3181731e58
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发表时间：
2008-12-01
影响因子：
3.1
通讯作者：
Kuten, Abraham
中科院分区：
文献类型：
--
作者：
Stein, Moshe E.;Bernstein, Zvi;Kuten, Abraham
在罕见癌症网络研究的框架内，我们检查了30例患有小细胞神经内分泌前列腺癌的患者，无论是在早期/局部或晚期/转移阶段。患者接受以顺铂为基础的化疗，伴或不伴盆腔放疗。两名早期疾病患者在19个月和22个月的时间内获得完全缓解。3例晚期疾病患者分别在6、7和54个月内获得完全缓解。25名患者死于严重的局部和/或远处失败。没有患者出现脑转移作为复发的初始部位。小细胞神经内分泌前列腺癌是一种侵袭性很强的疾病，即使是局限性的，预后也很差。尽管初始反应，常规顺铂为主的化疗加放疗未能明显改善预后。改善将来自于了解疾病的生物学，并将新的靶向疗法整合到这种罕见和侵袭性肿瘤的治疗中。
Within the framework of the Rare Cancer Network Study, we examined 30 patients suffering from small cell neuroendocrine prostate cancer, either in an early/localized or an advanced/metastatic stage. Patients were treated with cisplatin-based chemotherapy, with or without pelvic radiotherapy. Two patients with early disease achieved complete remission for a duration of 19 and 22 months. Three patients with advanced disease achieved complete remission for 6, 7, and 54 months, respectively. Twenty-five patients succumbed to massive local and/or distant failure. No patient presented with brain metastases as the initial site of relapse. Small cell neuroendocrine prostate carcinoma is a very aggressive disease with a poor prognosis, even in its localized form. Despite initial response, the common cisplatin-based chemotherapy plus radiotherapy failed to improve Outcome markedly. Improvement will come from understanding the biology of the disease and integrating new targeted therapies into the treatment of this rare and aggressive tumor.