Differential role of the accumbens Shell and Core subterritories in food-entrained rhythms of rats
Differential role of the accumbens Shell and Core subterritories in food-entrained rhythms of rats
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DOI：
10.1016/j.bbr.2004.08.016
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发表时间：
2005-03-07
影响因子：
2.7
通讯作者：
Escobar, C
中科院分区：
文献类型：
--
作者：
Mendoza, J;Angeles-Castellanos, M;Escobar, C
限制喂养时间表（RFS）夹带的行为和生理节律，即使在视交叉上核消融的动物，这表明存在的食物夹带振荡器。延髓核是表达动机行为的重要结构，由于其解剖学亚区，壳（Acc-Sh）和核心（Acc-Co）与不同的功能系统建立联系，它们可能以不同的方式参与食物夹带。第一个实验，探索了Acc-Sh和Acc-Co在食物夹带中的作用，使用蛋白质c-Fos作为转录激活标记的免疫组织化学检测。实验2检测了Acc一Sh和Acc一Co对NMDA兴奋性毒性损伤的差异效应。将损伤大鼠带入RFS，并评价运动活性和游离脂肪酸（FFA）浓度。结果数据表明，在Acc-Sh有一个增加的c-Fos免疫反应性的食物夹带大鼠主要是在喂养过程中，而c-Fos的表达在Ace-Co区域增加在喂养过程中，也预计用餐时间。FFA夹带在两个损伤组，但基础水平较低的核心病变大鼠。所有大鼠均表现出食物预期活动（FAA）。然而，FAA在壳损伤的动物中增加，而在核心损伤的大鼠中几乎被消除。这些数据表明，丘脑核参与行为和代谢的食物夹带，并有两个分区之间的差异作用。(C)2004 Elsevier B. V.保留所有权利。
Restricted feeding schedules (RFS) entrain behavioral and physiological rhythms even in suprachiasmatic nucleus ablated animals, suggesting the existence of a food-entrained oscillator. The nucleus accumbens is an important structure for the expression of motivational behaviors and because its anatomical subterritories, Shell (Acc-Sh) and Core (Acc-Co) establish connections with different functional systems, they may participate in a differential way in food-entrainment. A first experiment, explored the role of Acc-Sh and Acc-Co in food-entrainment using the immunohistochemical detection of the protein c-Fos as a transcriptional activation marker. Experiment 2 tested the differential effect of Acc-Sh and Acc-Co, NMDA excitotoxic lesions. Lesioned rats were entrained to RFS and locomotor activity and free fatty acids (FFA) concentrations were evaluated. Results data show that in the Acc-Sh there is an increase of c-Fos immunoreactivity in food-entrained rats principally during feeding, whereas c-Fos expression in the Ace-Co region was increased during feeding and also anticipating meal-time. FFA were entrained in both lesioned groups, but the basal level was lower in Core-lesion rats. All rats exhibited food anticipatory activity (FAA). However, FAA was increased in Shell-lesioned animals and was almost abolished in the Core-lesion rats. These data indicate that the accumbens nucleus is involved with behavioral and metabolic food-entrainment, and that there is a differential role between both subregions. (C) 2004 Elsevier B.V. All rights reserved.