Structural biology of bacterial pathogenesis
Structural biology of bacterial pathogenesis
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DOI：
10.1016/j.sbi.2004.03.004
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发表时间：
2004-04-01
影响因子：
6.8
通讯作者：
Waksman, G
中科院分区：
文献类型：
--
作者：
Remaut, H;Waksman, G
近年来，细菌致病相关蛋白的结构信息迅速增加。细菌与其宿主组织建立接触的不同模式通过与其同源宿主受体复合的细菌粘附素的结构来举例说明。随着I型和IV型分泌系统组分结构的确定，以及菌毛生物发生的分子伴侣-引导途径中纤维形成机制的阐明，对各种革兰氏阴性分泌系统的结构有了更详细的了解。最后，分泌的毒力因子结合到它们的宿主靶标的复合物的结构已经解开了细菌病原体利用细胞过程对其有利的机制。
Recent years have seen a rapid increase in structural information on proteins implicated in bacterial pathogenesis. The different modes by which bacteria establish contact with their host tissues are exemplified by the structures of bacterial adhesins in complex with their cognate host receptor. A more detailed structural understanding of the various Gram-negative secretion systems has emerged with the determination of the structures of type I and type IV secretion system components, and with the elucidation of the mechanism of fibre formation in the chaperone-usher pathway of pilus biogenesis. Finally, the structures of complexes of secreted virulence factors bound to their host targets have unravelled the mechanisms by which bacterial pathogens exploit cellular processes to their advantage.