Boric acid inhibits human prostate cancer cell proliferation
Boric acid inhibits human prostate cancer cell proliferation
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DOI：
10.1016/j.canlet.2004.06.001
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发表时间：
2004-12-08
期刊：
影响因子：
9.7
通讯作者：
Eckhert, CD
中科院分区：
文献类型：
--
作者：
Barranco, WT;Eckhert, CD
硼在生物学中的作用包括对混合细菌种群中基因表达的协调调节以及高等植物和低等动物的生长和增殖。在此，我们报道了血浆中硼的主要形式--硼酸，以剂量依赖的方式抑制前列腺癌DU-145和LNCaP细胞的增殖。非致癌前列腺细胞系PWR-1E和RWPE-1以及癌细胞系PC-3也受到抑制，但所需浓度高于观察到的人体血液浓度。使用DU-145细胞的研究表明，硼酸诱导了细胞死亡非依赖性的增殖抑制，对细胞周期分布和线粒体功能几乎没有影响。(C)2004爱思唯尔爱尔兰有限公司。保留所有权利。
The role of boron in biology includes coordinated regulation of gene expression in mixed bacterial populations and the growth and proliferation of higher plants and lower animals. Here we report that boric acid, the dominant form of boron in plasma, inhibits the proliferation of prostate cancer cell lines, DU-145 and LNCaP, in a dose-dependent manner. Non-tumorigenic prostate cell lines, PWR-1E and RWPE-1, and the cancer line PC-3 were also inhibited, but required concentrations higher than observed human blood levels. Studies using DU-145 cells showed that boric acid induced a cell death-independent proliferative inhibition, with little effect on cell cycle stage distribution and mitochondrial function. (C) 2004 Elsevier Ireland Ltd. All rights reserved.