ROLE OF PEDAL GANGLIA MOTOR NEURONS IN PEDAL WAVE GENERATION IN APLYSIA
ROLE OF PEDAL GANGLIA MOTOR NEURONS IN PEDAL WAVE GENERATION IN APLYSIA
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DOI：
10.1016/0361-9230(80)90191-4
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发表时间：
1980-01-01
影响因子：
3.8
通讯作者：
JAHANPARWAR, B
中科院分区：
文献类型：
--
作者：
FREDMAN, SM;JAHANPARWAR, B
假定足神经节运动神经元参与足波的产生，在足部的健忘症进行了检查。在没有踏板波的情况下，踏板运动神经元紧张地发射，但在踏板波产生过程中表现出恒定相位角的爆发。运动神经元在180 °和180 °内都爆裂。与踏板波的相位不同。大相位角神经元放电的相对潜伏期比小相位角神经元放电的相对潜伏期更易变。足神经元之间没有单突触连接。它们在踏板波期间和不存在踏板波的情况下的放电是由于突触输入，推测是来自产生踏板波下的振荡的中间神经元。同相放电的运动神经元具有相同符号的共同突触输入，而异相放电的运动神经元具有相反符号的共同突触输入。在足运动神经元之间似乎也存在多突触连接。运动神经元对振荡中间神经元的多突触反馈被提出。这一结果与多神经元振荡器一致，其中不同的元件驱动不同的运动神经元组。踏板波是振荡器网络周期性激活运动神经元的结果。足运动神经元诱发几种不同类型的紧张变化时，在脚细胞内刺激。观察到快速和缓慢的张力增加。有些神经元在受到刺激时会导致足部张力降低，它们可能是抑制性运动神经元。其他神经元似乎参与足紧张的中枢控制。足运动神经元的传导速度为36-136 cm/s，轴突分布于1个以上的足神经分支。这种性质可能有助于踏板波的纵向扩展。
Presumptive pedal ganglia motor neurons involved in pedal wave generation in the foot of Aplysia were examined. Pedal motor neurons fired tonicly in the absence of pedal waves, but exhibited bursting with constant phase angles during pedal wave generation. Motor neurons which burst both in and 180.degree. out of phase with the pedal wave were recorded. The relative latency of neurons firing at large phase angles was more variable than that of neurons firing at small phase angles. Pedal neurons did not make monosynaptic connections among themselves. Their firing during and in the absence of pedal waves was due to synaptic input, presumably from interneurons which generate the oscillations underlying the pedal wave. Motor neurons firing in phase had common synaptic input of the same sign, while some motor neurons firing out of phase had common synaptic input of the opposite sign. There also appeared to be polysynaptic connections among pedal motor neurons. Polysynaptic feedback from the motor neurons to the oscillator interneurons was suggested. The results are consistent with a multineuronal oscillator in which different elements drive different groups of motor neurons. The pedal wave is the result of cyclic activation of the motor neurons by the oscillator network. Pedal motor neurons evoked several different types of tension changes in the foot when intracellularly stimulated. Fast and slow tension increases were observed. Some caused decreased tension in the foot when stimulated; they might be inhibitory motor neurons. Other neurons appeared to be involved in the central control of foot tonus. Pedal motor neurons had conduction velocities ranging from 36-136 cm/s and had axons in more than 1 foot nerve branch. This property may contribute to the longitudinal spread of the pedal wave.