Intra-cerebellar infusion of NMDA receptor antagonist AP5 disrupts classical eyeblink conditioning in rabbits
Intra-cerebellar infusion of NMDA receptor antagonist AP5 disrupts classical eyeblink conditioning in rabbits
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DOI：
10.1016/s0006-8993(00)03005-5
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发表时间：
2000-12-22
期刊：
影响因子：
2.9
通讯作者：
Steinmetz, JE
中科院分区：
文献类型：
--
作者：
Chen, GX;Steinmetz, JE
在用音调条件刺激和吹气非条件刺激进行经典眨眼调节期间，将 AP5（一种 NMDA 受体拮抗剂）注入兔子的小脑间核区域。在注射AP5的兔子中，条件性眨眼反应的获得被延迟，但当这些相同的兔子在达到渐近反应水平后第二次注射时，NMDA受体拮抗剂对条件性反应几乎没有影响。一些在充分了解条件反应后首次接受 AP5 输注的兔子表现出反应时间的暂时改变。这些数据表明，NMDA 受体活性参与经典条件性眨眼反应的获得，并且还可能参与调节涉及反应计时和条件性反应执行的其他方面的细胞过程。 (C) 2000 Elsevier Science B.V. 保留所有权利。
Rabbits were infused with AP5, an NMDA receptor antagonist, into the region of the cerebellar interpositus nucleus during classical eyeblink conditioning with a tone conditioned stimulus and an air puff unconditioned stimulus. Acquisition of the conditioned eyeblink response was delayed in rabbits infused with AP5 but the NMDA receptor antagonist had little effect on conditioned responses when these same rabbits were infused a second time after reaching asymptotic responding levels. Some rabbits that received AP5 infusions for the first time after the conditioned response was well learned showed temporary alterations in response timing. These data indicate that NMDA receptor activity is involved in the acquisition of classically conditioned eyeblink response and may also be involved in regulating cellular processes involved in response timing and other aspects of conditioned response execution. (C) 2000 Elsevier Science B.V. All rights reserved.