Using human extra-cortical local field potentials to control a switch
Using human extra-cortical local field potentials to control a switch
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DOI：
10.1088/1741-2560/1/2/002
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发表时间：
2004-06-01
影响因子：
4
通讯作者：
Moore, Melody
中科院分区：
文献类型：
--
作者：
Kennedy, Philip;Andreasen, Dinal;Moore, Melody
患有严重瘫痪和沉默症的人需要沟通渠道。传统的辅助技术设备最终会失败，特别是对于逐渐完全被锁定的肌萎缩侧索硬化症 (ALS) 受试者。提供开关功能的直接脑机接口可以为外界提供直接的沟通通道。由于颅骨和头皮衰减以及环境噪声，从头皮电极记录的脑电图 (EEG) 信号显着降低。使用导电颅骨螺钉的本系统可以更可靠地访问皮质局部场电位（LFP），而无需进入大脑本身。我们描述了一名几乎被锁定的 ALS 人类受试者，他使用在线时域检测技术激活了开关。对 LFP 活动的频域分析表明这是检测开关激活意图的另一种方法。有了这个大脑通讯系统，我们可以合理地预期，被锁定但认知完好的人类将始终能够进行交流。
Individuals with profound paralysis and mutism require a communication channel. Traditional assistive technology devices eventually fail, especially in the case of amyotrophic lateral sclerosis (ALS) subjects who gradually become totally locked-in. A direct brain-to-computer interface that provides switch functions can provide a direct communication channel to the external world. Electroencephalographic (EEG) signals recorded from scalp electrodes are significantly degraded due to skull and scalp attenuation and ambient noise. The present system using conductive skull screws allows more reliable access to cortical local field potentials (LFPs) without entering the brain itself. We describe an almost locked-in human subject with ALS who activated a switch using online time domain detection techniques. Frequency domain analysis of his LFP activity demonstrates this to be an alternative method of detecting switch activation intentions. With this brain communicator system it is reasonable to expect that locked-in, but cognitively intact, humans will always be able to communicate.