Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy
Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy
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DOI：
10.1016/j.yjmcc.2007.04.004
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发表时间：
2007-06-01
影响因子：
5
通讯作者：
Wang, Da-Zhi
中科院分区：
文献类型：
--
作者：
Tatsuguchi, Mariko;Seok, Hee Young;Wang, Da-Zhi
MicroRNAs （miRNAs）是最近发现的一类类似于22核苷酸调控rna的转录后调控基因表达的rna。我们最近证明了肌肉特异性mirna miR-1和miR-133在调节肌肉增殖和分化中发挥重要作用。在这里，我们研究了mirna在心脏肥厚中的作用。我们分析了激动剂诱导的肥厚心肌细胞和压力过载诱导的肥厚心脏中miRNA的整体表达，发现miRNA表达谱在这些肥厚条件下发生了变化。我们进一步表明抑制内源性miR-21或miR-18b会增加肥厚性生长。相反，将功能性miR-21或miR-18b引入心肌细胞可抑制心肌细胞肥大。总之，我们的研究指出mirna是心脏肥厚的关键调节因子。(C) 2007爱思唯尔公司版权所有。
MicroRNAs (miRNAs) are a recently discovered class of similar to 22-nucleotide regulatory RNAs that post-transcriptionally regulate gene expression. We have recently demonstrated that muscle-specific miRNAs miR-1 and miR-133 play an important role in modulating muscle proliferation and differentiation. Here, we investigate the involvement of miRNAs in cardiac hypertrophy. We analyzed the global expression of miRNAs in agonist-induced hypertrophic cardiomyocytes as well as in pressure overload-induced hypertrophic hearts and found the miRNA expression profile altered in those hypertrophic conditions. We further show that inhibition of endogenous miR-21 or miR-18b augments hypertrophic growth. Conversely, introduction of functional miR-21 or miR-18b into cardiomyocytes represses myocyte hypertrophy. Together, our studies point to miRNAs as critical regulators of cardiac hypertrophy. (C) 2007 Elsevier Inc. All rights reserved.