Genomic Analyses Reveal the Influence of Geographic Origin, Migration, and Hybridization on Modern Dog Breed Development.
Genomic Analyses Reveal the Influence of Geographic Origin, Migration, and Hybridization on Modern Dog Breed Development.
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DOI：
10.1016/j.celrep.2017.03.079
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发表时间：
2017-04-25
期刊：
影响因子：
8.8
通讯作者：
Ostrander EA
中科院分区：
文献类型：
--
作者：
Parker HG;Dreger DL;Rimbault M;Davis BW;Mullen AB;Carpintero-Ramirez G;Ostrander EA
有近400种现代家养狗品种，它们有着独特的历史和基因特征。为了追踪品种发育的遗传特征，我们收集了最多样化的犬种数据集，反映了它们广泛的表型变异和遗传。结合遗传距离、迁移和全基因组单倍型共享分析，我们揭示了共同性状发展的地理模式和独立起源。我们的分析揭示了品种的杂交历史，阐明了移民的影响，首次揭示了一些现代品种中新世界犬的建议。最后，我们使用分支学和单倍型共享来显示一些共同特征在狗的历史上不止一次出现。这些分析表征了品种发展的复杂性，解决了长期存在的问题，如单个品种起源、迁移对地理上不同品种的影响，以及推断犬种之间性状和疾病等位基因的转移。
There are nearly 400 modern domestic dog breeds with a unique histories and genetic profiles. To track the genetic signatures of breed development, we have assembled the most diverse dataset of dog breeds, reflecting their extensive phenotypic variation and heritage. Combining genetic distance, migration, and genome-wide haplotype sharing analyses, we uncover geographic patterns of development and independent origins of common traits. Our analyses reveal the hybrid history of breeds and elucidate the effects of immigration, revealing for the first time a suggestion of New World dog within some modern breeds. Finally, we used cladistics and haplotype sharing to show that some common traits have arisen more than once in the history of the dog. These analyses characterize the complexities of breed development resolving long standing questions regarding individual breed origination, the effect of migration on geographically distinct breeds, and by inference, transfer of trait and disease alleles among dog breeds.